Teaches fundamental knowledge about protein structures, protein interactions and protein folding. Discusses in detail the most common methods on how proteins and macromolecular complexes are studied, such as X-ray crystallography, NMR-spectroscopy and electron microscopy. Offers about 50 percent direct teaching, 40 percent discussion of papers in a journal club style and 10 percent hands-on practicals on software packages relevant to structural biology. Recommended prerequisite: MCDB 2150 or EBIO 2070 (minimum grade C-). Formerly MCDB 4501.