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Chen, Zhe Asst Research Professor

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Research Areas research areas

Research

research overview

  • During embryonic development, cellular extensions of neurons called axons grow out and navigate to their correct targets through the biological process of axon guidance, which is central to the formation of a functional nervous system. Defects in axon guidance can lead to many neurological disorders, such as mental retardation, social disabilities including autism, motor defects including mirror movement, and so on. As axons navigate through intricate cellular environment, they are often instructed by guidance cues and respond to these cues by precisely regulating the expression level and activity of transmembrane receptors on their surface. Dr. Chen's research aims to better understand the mechanisms that ensure the fidelity of receptor function and thus axon guidance.

keywords

  • neural development, axon guidance, immunohistochemistry, alternative splicing, neuronal migration neurological disorders, cancers

Background

International Activities

global connections related to teaching and scholarly work (past 3 years)

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