subject area of

• 3'-Phosphatase activity in T4 polynucleotide kinase.  Journal Article
• 3'-terminal labelling of RNA with T4 RNA ligase.  Journal Article
• A Mechanistic Model of the Enzymatic Hydrolysis of Cellulose  Journal Article
• A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases  Journal Article
• A functional genetic screen reveals sequence preferences within a key tertiary interaction in cobalamin riboswitches required for ligand selectivity  Journal Article
• A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme  Journal Article
• A single-molecule analysis reveals morphological targets for cellulase synergy  Journal Article
• A universal mode of helix packing in RNA  Journal Article
• ACYCLIC GUANOSINE ANALOGS INHIBIT DNA POLYMERASE-ALPHA, POLYMERASE-DELTA, POLYMERASE-EPSILON WITH VERY DIFFERENT POTENCIES AND HAVE UNIQUE MECHANISMS OF ACTION  Journal Article
• ALTERATION OF SUBSTRATE-SPECIFICITY FOR THE ENDORIBONUCLEOLYTIC CLEAVAGE OF RNA BY THE TETRAHYMENA RIBOZYME  Journal Article
• AMINOACYL ESTERASE-ACTIVITY OF THE TETRAHYMENA RIBOZYME  Journal Article
• Adaptive Ligand Binding by the Purine Riboswitch in the Recognition of Guanine and Adenine Analogs  Journal Article
• Bacterial RNase P: a new view of an ancient enzyme  Journal Article
• Building specificity with nonspecific RNA-binding proteins  Journal Article
• CATALYSIS OF RNA CLEAVAGE BY A RIBOZYME DERIVED FROM THE GROUP-I INTRON OF ANABAENA PRE-TRNA(LEU)  Journal Article
• CATALYSIS OF RNA CLEAVAGE BY THE TETRAHYMENA-THERMOPHILA RIBOZYME .1. KINETIC DESCRIPTION OF THE REACTION OF AN RNA SUBSTRATE COMPLEMENTARY TO THE ACTIVE-SITE  Journal Article
• CATALYSIS OF RNA CLEAVAGE BY THE TETRAHYMENA-THERMOPHILA RIBOZYME .2. KINETIC DESCRIPTION OF THE REACTION OF AN RNA SUBSTRATE THAT FORMS A MISMATCH AT THE ACTIVE-SITE  Journal Article
• CHARACTERIZATION OF DEOXY-CONTAINING AND RIBO-CONTAINING OLIGONUCLEOTIDE SUBSTRATES IN THE HAMMERHEAD SELF-CLEAVAGE REACTION  Journal Article
• COMPARISON OF UBIQUINOL AND CYTOCHROME-C TERMINAL OXIDASES - AN ALTERNATIVE VIEW  Journal Article
• CONTRIBUTIONS OF 2'-HYDROXYL GROUPS OF THE RNA SUBSTRATE TO BINDING AND CATALYSIS BY THE TETRAHYMENA RIBOZYME - AN ENERGETIC PICTURE OF AN ACTIVE-SITE COMPOSED OF RNA  Journal Article
• CYTOSOLIC PHOSPHOLIPASE-C ACTIVITY .1. EVIDENCE FOR COUPLING WITH CYTOSOLIC GUANINE-NUCLEOTIDE-BINDING PROTEIN, GI-ALPHA  Journal Article
• CYTOSOLIC PHOSPHOLIPASE-C ACTIVITY .2. RELATIONSHIP TO CONCANAVALIN A-INDUCED PHOSPHATIDYLINOSITOL-TURNOVER IN SPLENOCYTES  Journal Article
• Catalytic reaction pathway for the mitogen-activated protein kinase ERK2  Journal Article
• Chiral histidine selection by D-ribose RNA  Journal Article
• Circular substrates of the hammerhead ribozyme shift the internal equilibrium further toward cleavage  Journal Article
• ClpS is an essential component of the N-end rule pathway in Escherichia coli  Journal Article
• Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding  Journal Article
• Control of Metal Catalyst Selectivity through Specific Noncovalent Molecular Interactions  Journal Article
• Crystal Structure of YaeT: Conformational Flexibility and Substrate Recognition  Journal Article
• Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid a modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance  Journal Article
• Crystal structure of HsIUV complexed with a vinyl sulfone inhibitor: Corroboration of a proposed mechanism of allosteric activation of HsIV by HsIU  Journal Article
• DEFINING A SMALLER RNA SUBSTRATE FOR ELONGATION-FACTOR TU  Journal Article
• DETERMINATION OF RECOGNITION NUCLEOTIDES FOR ESCHERICHIA-COLI PHENYLALANYL-TRANSFER RNA-SYNTHETASE  Journal Article
• DETERMINATION OF RNA PROTEIN CONTACTS USING THIOPHOSPHATE SUBSTITUTIONS  Journal Article
• DNA POLYMERASE-EPSILON - APHIDICOLIN INHIBITION AND THE RELATIONSHIP BETWEEN POLYMERASE AND EXONUCLEASE ACTIVITY  Journal Article
• DNA polymerase III of Escherichia coli. Purification and identification of subunits.  Journal Article
• DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.  Journal Article
• DNMT1-interacting RNAs block gene-specific DNA methylation  Journal Article
• Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6  Journal Article
• Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning  Journal Article
• Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases  Journal Article
• Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins.  Journal Article
• Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF(65) and the splicing repressor sex-lethal  Journal Article
• Discrimination between Right and Wrong Purine dNTPs by DNA Polymerase I from Bacillus stearothermophilus  Journal Article
• Duplex destabilization by four ribosomal DEAD-box proteins.  Journal Article
• Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA  Journal Article
• Efficient ligation of the Schistosoma hammerhead ribozyme  Journal Article
• Empirical Evaluation of Inhibitory Product, Substrate, and Enzyme Effects During the Enzymatic Saccharification of Lignocellulosic Biomass  Journal Article
• Escherichia coli DbpA is a 3' --> 5' RNA helicase.  Journal Article
• Escherichia coli DbpA is an RNA helicase that requires hairpin 92 of 23S rRNA  Journal Article
• Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723  Journal Article
• Exocyclic amine of the conserved G center dot U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization  Journal Article
• Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha  Journal Article
• Exploring the specificity of bacterial elongation factor Tu for different tRNAs.  Journal Article
• Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma  Journal Article
• GUANOSINE BINDING TO THE TETRAHYMENA RIBOZYME - THERMODYNAMIC COUPLING WITH OLIGONUCLEOTIDE BINDING  Journal Article
• Glycoside Hydrolase Processivity Is Directly Related to Oligosaccharide Binding Free Energy  Journal Article
• Hammerhead cleavage of the phosphorodithioate linkage  Journal Article
• Hammerhead ribozymes with a faster cleavage rate  Journal Article
• Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase  Journal Article
• Herpes simplex virus 1 primase employs watson-crick hydrogen bonding to identify cognate nucleoside triphosphates.  Journal Article
• Histone chaperone specificity in Rtt109 activation  Journal Article
• How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA  Journal Article
• Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity  Journal Article
• Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates  Journal Article
• Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels  Journal Article
• IDENTIFICATION OF RIBOZYMES WITHIN A RIBOZYME LIBRARY THAT EFFICIENTLY CLEAVE A LONG SUBSTRATE RNA  Journal Article
• INACTIVATION OF DNA-POLYMERASE ALPHA-PRIMASE BY ACROLEIN - LOSS OF ACTIVITY DEPENDS ON THE DNA SUBSTRATE  Journal Article
• ISOLATION OF HIGH-AFFINITY RNA LIGANDS TO HIV-1 INTEGRASE FROM A RANDOM POOL  Journal Article
• Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases  Journal Article
• Identification of CED-3 substrates by a yeast-based screening method  Journal Article
• Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics  Journal Article
• Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13  Journal Article
• Idiosyncratic tuning of tRNAs to achieve uniform ribosome binding.  Journal Article
• In vitro selection of RNA specifically cleaved by bacteriophage T4 RegB endonuclease  Journal Article
• In vitro selection of a novel catalytic RNA: Characterization of a sulfur alkylation reaction and interaction with a small peptide  Journal Article
• Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A(2)  Journal Article
• Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations.  Journal Article
• Initial- and Processive-Cut Products Reveal Cellobiohydrolase Rate Limitations and the Role of Companion Enzymes  Journal Article
• Interactions of Escherichia coli RNA with bacteriophage MS2 coat protein: genomic SELEX  Journal Article
• Joining of RNA molecules with RNA ligase.  Journal Article
• KINETICS OF INTERMOLECULAR CLEAVAGE BY HAMMERHEAD RIBOZYMES  Journal Article
• Kinetic analysis of the RNA-dependent adenosinetriphosphatase activity of DbpA, an Escherichia coli DEAD protein specific for 23S ribosomal RNA  Journal Article
• Kinetic characterization of two I/II format hammerhead ribozymes  Journal Article
• METAL-ION REQUIREMENTS FOR SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME  Journal Article
• MUTATIONS AT THE GUANOSINE-BINDING SITE OF THE TETRAHYMENA RIBOZYME ALSO AFFECT SITE-SPECIFIC HYDROLYSIS  Journal Article
• MUTATIONS IN A NONCONSERVED SEQUENCE OF THE TETRAHYMENA RIBOZYME INCREASE ACTIVITY AND SPECIFICITY  Journal Article
• Material-based regulation of the myofibroblast phenotype  Journal Article
• Mechanism of substrate recognition by Hsp70 chaperones  Conference Proceeding
• Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate  Journal Article
• Modifying the specificity of an RNA backbone contact  Journal Article
• Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain  Journal Article
• Monitoring post-translational modification of proteins with allosteric ribozymes  Journal Article
• Multiple Turnovers of the Nicotino-Enzyme PdxB Require alpha-Keto Acids as Cosubstrates  Journal Article
• NUCLEAR-MAGNETIC-RESONANCE STUDIES OF THE HAMMERHEAD RIBOZYME DOMAIN - SECONDARY STRUCTURE FORMATION AND MAGNESIUM-ION DEPENDENCE  Journal Article
• Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID-Mediated Mutagenesis  Journal Article
• Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors  Journal Article
• ONE BINDING-SITE DETERMINES SEQUENCE SPECIFICITY OF TETRAHYMENA PRE-RIBOSOMAL-RNA SELF-SPLICING, TRANSSPLICING, AND RNA ENZYME-ACTIVITY  Journal Article
• Parallel Multiplicative Target Screening against Divergent Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential  Journal Article
• Pentachlorophenol Hydroxylase, a Poorly Functioning Enzyme Required for Degradation of Pentachlorophenol by Sphingobium chlorophenolicum  Journal Article
• Peptide bond formation by in vitro selected ribozymes  Journal Article
• Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features  Journal Article
• Pot1, the putative telomere end-binding protein in fission yeast and humans  Journal Article
• Product binding varies dramatically between processive and nonprocessive cellulase enzymes.  Journal Article
• Promiscuity rules? The dispensability of cyclin E and Cdk2.  Journal Article
• Promoter scanning for transcription inhibition with DNA-binding polyamides  Journal Article
• Proteornics and genomics: Perspectives on drug and target discovery  Journal Article
• Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3' overhang  Journal Article
• RECOGNITION OF YEAST TRANSFER RNA(PHE) BY ITS COGNATE YEAST PHENYLALANYL-TRANSFER RNA-SYNTHETASE - AN ANALYSIS OF SPECIFICITY  Journal Article
• RIBOZYME RECOGNITION OF RNA BY TERTIARY INTERACTIONS WITH SPECIFIC RIBOSE 2'-OH GROUPS  Journal Article
• RNA CATALYSIS BY A GROUP-I RIBOZYME - DEVELOPING A MODEL FOR TRANSITION-STATE STABILIZATION  Journal Article
• RNA SUBSTRATE BINDING-SITE IN THE CATALYTIC CORE OF THE TETRAHYMENA RIBOZYME  Journal Article
• RNA aptamers as pathway-specific MAP kinase inhibitors  Journal Article
• RNA tertiary folding monitored by fluorescence of covalently attached pyrene  Journal Article
• Reactions at the termini of tRNA with T4 RNA ligase.  Journal Article
• Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding  Journal Article
• Recognition of S-adenosylmethionine by riboswitches  Journal Article
• SELF-SPLICING AND ENZYMATIC CLEAVAGE OF RNA BY A GROUP-I INTERVENING SEQUENCE  Journal Article
• SPECIFICITY FOR 3',5'-LINKED SUBSTRATES IN RNA-CATALYZED RNA POLYMERIZATION  Journal Article
• SYNTHESIS OF SMALL RNAS USING T7 RNA-POLYMERASE  Journal Article
• Selective binding of Escherichia coli RNA polymerase to topoisomers of minicircles carrying the TAC16 and TAC17 promoters.  Journal Article
• Sequence-specific and 3 '-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit  Journal Article
• Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides  Journal Article
• Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol  Journal Article
• Simultaneous multiple substrate tag detection with ESI-ion trap MS for in vivo bacterial enzyme activity profiling  Journal Article
• Single-Stranded DNA-Binding Proteins: Multiple Domains for Multiple Functions  Journal Article
• Single-stranded RNA recognition by the bacteriophage T4 translational repressor, RegA  Journal Article
• Site-directed mutagenesis reveals the thermodynamic requirements for single-stranded DNA recognition by the telomere-binding protein Cdc13  Journal Article
• Solution structure of RNase P RNA  Journal Article
• Specific interaction of anticodon loop residues with yeast phenylalanyl-tRNA synthetase.  Journal Article
• Specificity of hammerhead ribozyme cleavage  Journal Article
• Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative Bacteria  Journal Article
• Structural Basis of Selective Ubiquitination of TRF1 by SCFFbx4  Journal Article
• Structural and mechanistic insights into Mps1 kinase activation  Journal Article
• Structural basis of the phosphorylation-independent recognition of cydin D1 by the SCFFBXO31 ubiquitin ligase  Journal Article
• Structural perspective on the activation of RNase P RNA by protein  Journal Article
• Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme  Journal Article
• Structure and mechanism of ArnA: Conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance  Journal Article
• Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans  Journal Article
• Structure of the Tetrahymena ribozyme: Base triple sandwich and metal ion at the active site  Journal Article
• Substrate recognition by the AAA plus chaperone ClpB  Journal Article
• Switching human telomerase on and off with hPOT1 protein in vitro  Journal Article
• Synthesis of nucleotide analogues that potently and selectively inhibit human DNA primase  Journal Article
• T4 RNA ligase as a nucleic acid synthesis and modification reagent.  Journal Article
• THE BACTERIOPHAGE-T4 REGB RIBONUCLEASE - STIMULATION OF THE PURIFIED ENZYME BY RIBOSOMAL-PROTEIN-S1  Journal Article
• THE IMPORTANCE OF BEING RIBOSE AT THE CLEAVAGE SITE IN THE TETRAHYMENA RIBOZYME REACTION  Journal Article
• THE INTERNAL EQUILIBRIUM OF THE HAMMERHEAD RIBOZYME REACTION  Journal Article
• THE TETRAHYMENA INTERVENING SEQUENCE RIBONUCLEIC-ACID ENZYME IS A PHOSPHOTRANSFERASE AND AN ACID-PHOSPHATASE  Journal Article
• THE TETRAHYMENA RIBOZYME ACTS LIKE AN RNA RESTRICTION ENDONUCLEASE  Journal Article
• TRIM5 alpha( )Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation  Journal Article
• The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease  Journal Article
• The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator  Journal Article
• The Tetrahymena ribozyme cleaves a 5 '-methylene phosphonate monoester similar to 10(2)-fold faster than a normal phosphate diester: Implications for enzyme catalysis of phosphoryl transfer reactions  Journal Article
• The bipartite architecture of the sRNA in an archaeal box C/D complex is a primary determinant of specificity  Journal Article
• The carboxy-terminal domain of the DExD/H protein YxiN is sufficient to confer specificity for 23 S rRNA  Journal Article
• The chemical repertoire of natural ribozymes  Journal Article
• The tRNA specificity of Thermus thermophilus EF-Tu  Journal Article
• Thermodynamic dissection of the substrate-ribozyme interaction in the hammerhead ribozyme  Journal Article
• Total Synthesis of Dermostatin A  Journal Article
• Ubiquitination of p21(Cip1/WAF1) by SCFSkp2: Substrate requirement and ubiquitination site selection  Journal Article
• Ubiquitination of p27(Kip1) requires physical interaction with cyclin E and probable phosphate recognition by SKP2  Journal Article
• Understanding histone acetyltransferase Rtt109 structure and function: how many chaperones does it take?  Journal Article
• Use of T4 RNA ligase to construct model substrates for a ribosomal RNA maturation endonuclease.  Journal Article
• Versatile derivatives of carbohydrate-binding modules for imaging of complex carbohydrates approaching the molecular level of resolution  Journal Article
• Yeast telomerase is specialized for C/A-rich RNA templates  Journal Article
• c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro  Journal Article
• tRNA conformity  Journal Article