Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Journal Article uri icon

Overview

abstract

  • Whereas it is known that voltage-gated calcium channels play important roles during development, potential embryonic roles of voltage-gated sodium channels have received much less attention. Voltage-gated sodium channels consist of pore-forming alpha-subunits (Na(v)1) and auxiliary beta-subunits. Here, we report the embryonic and larval expression patterns for all eight members of the gene family (scna) coding for zebrafish Na(v)1 proteins. We find that each scna gene displays a distinct expression pattern that is temporally and spatially dynamic during embryonic and larval stages. Overall, our findings indicate that scna gene expression occurs sufficiently early during embryogenesis to play developmental roles for both muscle and nervous tissues.

publication date

  • July 1, 2006

Full Author List

  • Novak AE; Taylor AD; Pineda RH; Lasda EL; Wright MA; Ribera AB

Other Profiles

Additional Document Info

start page

  • 1962

end page

  • 1973

volume

  • 235

issue

  • 7