Task-induced deactivation from rest extends beyond the default mode brain network. Journal Article uri icon

Overview

abstract

  • Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.

publication date

  • January 1, 2011

Full Author List

  • Harrison BJ; Pujol J; Contreras-Rodríguez O; Soriano-Mas C; López-Solà M; Deus J; Ortiz H; Blanco-Hinojo L; Alonso P; Hernández-Ribas R

Other Profiles

Additional Document Info

start page

  • e22964

volume

  • 6

issue

  • 7