Enhanced inflammation with high carbohydrate intake during recovery from eccentric exercise. Journal Article uri icon



  • Inflammation associated with adipose tissue is modulated by macronutrient availability. For example, glucose increases inflammation in obese but not lean individuals. Little is known about how macronutrient intake influences inflammation associated with muscle. The aim of this study was to determine the impact of macronutrient intake differences during recovery from eccentric exercise on the inflammatory response. The study was a cross-over design in which young men and women (n = 12) completed high and low carbohydrate (CHO) conditions. Both conditions consisted of six sets of ten maximal high-force eccentric contractions of the elbow flexors and extensors followed by a controlled diet for the first 8 h post-exercise. Glucose, insulin, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and C-reactive protein were measured from blood samples pre-exercise, 1.5, 4, 8, and 24 h post-exercise. Perceived muscle soreness, strength loss, and serum CK activity were measured through 120 h post-exercise. Perceived soreness was elevated (P < 0.001) at all time points post-exercise in both conditions and was higher (P < 0.05) in the high compared to the low CHO condition. IL-1beta increased (P = 0.05) 24 h post-exercise in the high compared to the low CHO condition. There was a trend (P = 0.06) for IL-6 to be elevated in the high compared to the low CHO condition. We conclude that inflammation induced by high-force eccentric exercise in skeletal muscle is greater when a high CHO compared to a low CHO diet is consumed during recovery.

publication date

  • August 1, 2010

has subject area

has restriction

  • green

Date in CU Experts

  • March 13, 2015 12:11 PM

Full Author List

  • Depner CM; Kirwan RD; Frederickson SJ; Miles MP

author count

  • 4

citation count

  • 5

Other Profiles

International Standard Serial Number (ISSN)

  • 1439-6319

Electronic International Standard Serial Number (EISSN)

  • 1439-6327

Additional Document Info

start page

  • 1067

end page

  • 1076


  • 109


  • 6