Modulation of LINE-1 Retrotransposition by a Human SAMHD1 Polymorphism. Journal Article uri icon

Overview

abstract

  • The HIV-1 restriction factor SAMHD1 has the ability to negatively modulate retrotransposition of the long interspersed element 1(LINE-1). By exploring the ability of human SAMHD1 polymorphisms to inhibit LINE-1, we found that the single nucleotide polymorphism S33A present in the Korean population lose the ability to inhibit LINE-1 retrotransposition. Because SAMHD1 residue S33 is phosphorylated in human cycling and non-cycling cells, we demonstrated that SAMHD1 requires to be either phosphorylated on position 33 or to contain a bulky residue in order to inhibit LINE-1 retrotransposition. Therefore this unique mutation uncouples functions in this important restriction factor.

publication date

  • December 1, 2016

Full Author List

  • White TE; Brandariz-Nuñez A; Han K; Sawyer SL; Kim B; Diaz-Griffero F

Other Profiles

Additional Document Info

start page

  • 53

end page

  • 60

volume

  • 6