Interleukin 1 alpha and an interleukin 1 beta fragment are somnogenic Journal Article uri icon



  • The somnogenic activity of interleukin 1 beta (IL-1 beta) has previously been established. Interleukin 1 alpha (IL-1 alpha) is a distinct gene product that possesses similar biological activities. We report here that IL-1 alpha, like IL-1 beta, has the capacity in rabbits to enhance non-rapid-eye-movement sleep, electroencephalographic slow-wave (0.5-3.5 Hz) voltages, and body temperatures and to inhibit rapid-eye-movement sleep. After IL-1 alpha, sleep remained episodic, and at the doses used no abnormal behavior was observed. Several synthetic IL-1 alpha and IL-1 beta peptides were also tested in vivo for somnogenic and pyrogenic activity and in vitro for their ability to stimulate prostaglandin E2 (PGE2) production by fibroblasts and proliferation of T-cells. Only IL-1 beta-(208-240) enhanced non-rapid-eye-movement sleep and body temperature, although both IL-1 beta-(208-240) and IL-1 alpha-(223-250) stimulated PGE2 production; both of these peptides failed to stimulate T-cell production. In contrast, four other IL-1 peptides were nonpyrogenic and somnogenically inactive yet stimulated T-cell proliferation. We conclude that the components of IL-1 required for sleep and temperature activities are different from those required for T-cell proliferation

publication date

  • September 1, 1990

Date in CU Experts

  • January 29, 2018 5:17 AM

Full Author List

  • Obal F; Opp M; Cady AB; Johannsen L; Postlethwaite AE; Poppleton HM; Seyer JM; Krueger JM

author count

  • 8

Additional Document Info

start page

  • R439

end page

  • R446


  • 259


  • 3 Pt 2