A thermodynamical model for stress-fiber organization in contractile cells. Journal Article uri icon

Overview

abstract

  • Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell's mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and different substrate stiffness. Our results demonstrate that the stress fibers viscoelastic behavior plays a crucial role in their formation and organization and shows good consistency with various experiments.

publication date

  • January 1, 2012

Full Author List

  • Foucard L; Vernerey FJ

Other Profiles

Additional Document Info

start page

  • 13702

end page

  • 137024

volume

  • 100

issue

  • 1