Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro. Journal Article uri icon



  • Candida albicans must penetrate the endothelial cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infection. We compared 27 C. albicans mutants with their wild-type parent for their capacity to damage endothelial cells in vitro and cause a lethal infection in mice following tail vein inoculation. Of 10 mutants with significantly impaired capacity to damage endothelial cells, all had attenuated virulence. Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis.

publication date

  • January 1, 2004

has subject area

Full Author List

  • Sanchez AA; Johnston DA; Myers C; Edwards JE; Mitchell AP; Filler SG

Other Profiles

Additional Document Info

start page

  • 598

end page

  • 601


  • 72


  • 1