TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction Journal Article uri icon



  • Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively uncharacterized. Here, we discover a novel regulator of Wnt signaling pathway called transmembrane protein 132A (TMEM132A). Our evidence shows a physical and functional interaction of TMEM132A with the Wnt ligand transporting protein Wntless (WLS). We show that TMEM132A stabilizes Wnt ligand, enhances WLS–Wnt ligand interaction, and activates the Wnt signaling pathway. Our results shed new light on the cellular mechanism underlying the fundamental aspect of WNT secretion from Wnt signal sending cells.

publication date

  • November 26, 2020

has restriction

  • gold

Date in CU Experts

  • January 13, 2021 6:05 AM

Full Author List

  • Li B; Niswander LA

author count

  • 2

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 2296-634X

Additional Document Info


  • 8