Minireview: The Impact of Antenatal Therapeutic Synthetic Glucocorticoids on the Developing Fetal Brain Journal Article uri icon



  • AbstractThe life-threatening, emotional, and economic burdens of premature birth have been greatly alleviated by antenatal glucocorticoid (GC) treatment. Antenatal GCs accelerate tissue development reducing respiratory distress syndrome and intraventricular hemorrhage in premature infants. However, they can also alter developmental processes in the brain and trigger adverse behavioral and metabolic outcomes later in life. This review summarizes animal model and clinical studies that examined the impact of antenatal GCs on the developing brain. In addition, we describe studies that assess glucocorticoid receptor (GR) action in neural stem/progenitor cells (NSPCs) in vivo and in vitro. We highlight recent work from our group on two GR pathways that impact NSPC proliferation, ie, a nongenomic GR pathway that regulates gap junction intercellular communication between coupled NSPCs through site-specific phosphorylation of connexin 43 and a genomic pathway driven by differential promoter recruitment of a specific GR phosphoisoform.

publication date

  • May 1, 2015

has restriction

  • bronze

Date in CU Experts

  • February 3, 2021 3:33 AM

Full Author List

  • Peffer ME; Zhang JY; Umfrey L; Rudine AC; Monaghan AP; DeFranco DB

author count

  • 6

Other Profiles

International Standard Serial Number (ISSN)

  • 0888-8809

Electronic International Standard Serial Number (EISSN)

  • 1944-9917

Additional Document Info

start page

  • 658

end page

  • 666


  • 29


  • 5