Future changes in tropical cyclone (TC) activity over the western North Pacific (WNP) are analyzed using four regional climate models (RCMs) within the Coordinated Regional Climate Downscaling Experiment (CORDEX) for East Asia. All RCMs are forced by the HadGEM2-AO under the historical and representative concentration pathway (RCP) 8.5 scenarios, and are performed at about 50-km resolution over the CORDEX-East Asia domain. In the historical simulations (1980–2005), multi-RCM ensembles yield realistic climatology for TC tracks and genesis frequency during the TC season (June–November), although they show somewhat systematic biases in simulating TC activity. The future (2024–49) projections indicate an insignificant increase in the total number of TC genesis (+5%), but a significant increase in track density over East Asia coastal regions (+17%). The enhanced TC activity over the East Asia coastal regions is mainly related to vertical wind shear weakened by reduced meridional temperature gradient and increased sea surface temperature (SST) at midlatitudes. The future accumulated cyclone energy (ACE) of total TCs increases significantly (+19%) because individual TCs have a longer lifetime (+6.6%) and stronger maximum wind speed (+4.1%) compared to those in the historical run. In particular, the ACE of TCs passing through 25°N increases by 45.9% in the future climate, indicating that the destructiveness of TCs can be significantly enhanced in the midlatitudes despite the total number of TCs not changing greatly.