Individuals with bipolar disorder (BD) frequently refuse to accept an adequate treatment plan. We describe strategies to help people with BD overcome treatment refusal and accept adequate treatment. We describe several strategies aimed at helping the clinician increase the patient’s willingness to accept an adequate treatment plan. We also discuss strategies clinicians can use when negotiating a compromise treatment plan for patients who refuse to accept optimal treatment and for situations where the patient and clinician cannot negotiate a mutually agreeable treatment plan.