Theoretical principles of in vitro selection using combinatorial nucleic acid libraries. Journal Article uri icon

Overview

abstract

  • A new paradigm for drug discovery and biological research has developed from technologies that integrate combinatorial chemistry with rounds of selection and amplification, a technique called in vitro selection or systematic evolution of ligands by exponential enrichment (SELEX). This overview unit discusses nucleic acid libraries that can be used, affinity probability distributions, an equilibrium model for SELEX, and optimal conditions including concentrations and signal-to-noise ratios.

publication date

  • February 1, 2000

Full Author List

  • Vant-Hull B; Gold L; Zichi DA

Other Profiles

Additional Document Info

start page

  • Unit

end page

  • 9.1

volume

  • Chapter 9