Demographic history and genetic structure in pre-Hispanic Central Mexico. Journal Article uri icon



  • Aridoamerica and Mesoamerica are two distinct cultural areas in northern and central Mexico, respectively, that hosted numerous pre-Hispanic civilizations between 2500 BCE and 1521 CE. The division between these regions shifted southward because of severe droughts ~1100 years ago, which allegedly drove a population replacement in central Mexico by Aridoamerican peoples. In this study, we present shotgun genome-wide data from 12 individuals and 27 mitochondrial genomes from eight pre-Hispanic archaeological sites across Mexico, including two at the shifting border of Aridoamerica and Mesoamerica. We find population continuity that spans the climate change episode and a broad preservation of the genetic structure across present-day Mexico for the past 2300 years. Lastly, we identify a contribution to pre-Hispanic populations of northern and central Mexico from two ancient unsampled "ghost" populations.

publication date

  • May 12, 2023

has restriction

  • green

Date in CU Experts

  • August 30, 2023 12:40 PM

Full Author List

  • Villa-Islas V; Izarraras-Gomez A; Larena M; Campos EMP; Sandoval-Velasco M; Rodríguez-Rodríguez JE; Bravo-Lopez M; Moguel B; Fregel R; Garfias-Morales E

author count

  • 27

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Additional Document Info

start page

  • eadd6142


  • 380


  • 6645