Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy Journal Article uri icon



  • An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multiphoton microscopy for the detection of two-photon fluorescence and second harmonic generation signals. The unique configuration of this integrated microscope allows for the simultaneous acquisition of both anatomical (structural) and functional imaging information with particular emphasis for applications in the fields of tissue engineering and cell biology. In addition, the contemporary analysis of the spectroscopic features can enhance contrast by differentiating among different tissue components.

publication date

  • January 30, 2006

has restriction

  • green

Date in CU Experts

  • January 15, 2014 11:27 AM

Full Author List

  • Vinegoni C; Ralston T; Tan W; Luo W; Marks DL; Boppart SA

author count

  • 6

Other Profiles

International Standard Serial Number (ISSN)

  • 0003-6951

Electronic International Standard Serial Number (EISSN)

  • 1077-3118

Additional Document Info


  • 88


  • 5