A Common Genetic Variant Is Associated with Adult and Childhood Obesity Journal Article uri icon



  • ; Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the; INSIG2; gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.;

publication date

  • April 14, 2006

has restriction

  • closed

Date in CU Experts

  • January 23, 2014 10:52 AM

Full Author List

  • Herbert A; Gerry NP; McQueen MB; Heid IM; Pfeufer A; Illig T; Wichmann H-E; Meitinger T; Hunter D; Hu FB

author count

  • 23

Other Profiles

International Standard Serial Number (ISSN)

  • 0036-8075

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Additional Document Info

start page

  • 279

end page

  • 283


  • 312


  • 5771