Moonlighting is mainstream: Paradigm adjustment required Journal Article uri icon



  • AbstractMoonlighting – the performance of more than one function by a single protein – is becoming recognized as a common phenomenon with important implications for systems biology and human health. The different functions of a moonlighting protein may use different regions of the protein structure, or alternative structures that occur due to post‐translational modifications and/or differences in binding partners. Often the different functions of moonlighting proteins are used at different times or in different places. The existence of moonlighting functions complicates efforts to understand metabolic and regulatory networks, as well as physiological and pathological processes in organisms. Because moonlighting functions can play important roles in disease processes, an improved understanding of moonlighting proteins will provide new opportunities for pharmacological manipulations that specifically target a function involved in pathology while sparing physiologically important functions.

publication date

  • July 1, 2012

has restriction

  • closed

Date in CU Experts

  • April 24, 2014 10:17 AM

Full Author List

  • Copley SD

author count

  • 1

Other Profiles

International Standard Serial Number (ISSN)

  • 0265-9247

Electronic International Standard Serial Number (EISSN)

  • 1521-1878

Additional Document Info

start page

  • 578

end page

  • 588


  • 34


  • 7