Efficient Catalysis of Polysiloxane Synthesis by Silicatein α Requires Specific Hydroxy and Imidazole Functionalities. Journal Article uri icon



  • A protein isolated from a biosilica (shown schematically) catalyzes alkoxysilane polycondensation at neutral pH values and low temperatures. Replacement of either of two specific side chain functionalities (Ser-26 and His-165) significantly diminishes catalysis, supporting a reaction mechanism analogous to that of a well-known enzyme that is highly homologous to the silica protein. These results may be useful in the development of synthetic catalysts for environmentally benign synthesis of polysiloxanes.

publication date

  • March 15, 1999

Full Author List

  • Zhou Y; Shimizu K; Cha JN; Stucky GD; Morse DE

Other Profiles

Additional Document Info

start page

  • 779

end page

  • 782


  • 38


  • 6