This course is devoted to the mechanisms that drive cancer, with an emphasis on how the biochemistry of normal cells teaches us how regulation goes awry in cancer cells. The course will include an analysis of historical and current developments in cancer biology. Topics covered: principles of transformation, viral and cellular oncogenes, tumor suppressor genes, signal transduction, cell cycle, cell death, DNA damage and repair, cancer genetics, cancer genomics, cancer risk factors, carcinogens, chemotherapies, targeted therapies, drug resistance, modern technologies in cancer research.
