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Publications in VIVO
 

Spencer, Sabrina Leigh Assistant Professor

Positions

Research Areas research areas

Research

research overview

  • Research in my lab is focused on understanding how signaling events control cell fate. Studying these processes in single cells reveals remarkable cell-to-cell variability in response to stimuli, even among genetically identical cells in a uniform environment. We seek to understand the causes and consequences of this heterogeneity in the cellular response to stimuli. The stimuli we study include growth factors, cell stress, and targeted cancer therapeutics. To do this, we develop genetically encoded fluorescent sensors for signaling events of interest. We then use long-term live-cell microscopy and cell tracking to quantify the dynamics of upstream signals and link them to cell fate (proliferation, quiescence, apoptosis, differentiation). Our long-term goal is to understand the normal mechanistic functioning of signaling pathways that control proliferation, to understand how these signals go awry in cancer, and eventually to alter the fate of individual cells.

keywords

  • single-cell heterogeneity, time-lapse microscopy, cancer biology, systems biology, cell biology, cell cycle, signal transduction

Publications

selected publications

Teaching

courses taught

  • CHEM 4740 Biochemistry of Gene Transmission, Expression and Regulation (Spring 2019)
  • CHEM 5740 Biochemistry of Gene Transmission, Expression and Regulation (Spring 2019)
  • CHEM 6901 Research in Chemistry (Spring 2019)
  • CHEM 8991 Doctoral Dissertation (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Fall 2018)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • CHEM 8991 Doctoral Dissertation (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • CHEM 6901 Research in Chemistry (Summer 2018)
  • CHEM 8991 Doctoral Dissertation (Summer 2018)
  • CHEM 4740 Biochemistry of Gene Transmission, Expression and Regulation (Spring 2018)
  • CHEM 5740 Biochemistry of Gene Transmission, Expression and Regulation (Spring 2018)
  • CHEM 6901 Research in Chemistry (Spring 2018)
  • CHEM 8991 Doctoral Dissertation (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)

Background

awards and honors

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles