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Fillman, Christy L. Senior Instructor

Positions

Research Areas research areas

Research

research overview

  • Bacteriophage are viruses that infect bacteria. Phage are specific to the type of bacteria they infect. The mycobacteriophage, which are used as a model, are phage that were isolated using Mycobacterium smegmatis as a host. Some species of Mycobacterium are pathogenic to humans, such as Mycobacterium tuberculosis and Mycobacterium lepera, which cause tuberculosis and leprosy respectively. Many mycobacteriophage that infect M. smegmatis can also infect M. tuberculosis and/or M. lepera. These studies could lead to a greater understanding of the complex nature of mycobacteriophage biology and their potential use in treating disease. Current projects include characterization of temperate mycobacteriophage, designing a method to place phage into clusters based on analysis of structural proteins, and characterizing mycobacteriophage inteins.

keywords

  • bacteriophage genomics

Publications

selected publications

Teaching

courses taught

  • MCDB 1161 - From Dirt to DNA: Phage Genomics Laboratory I
    Primary Instructor - Spring 2018 / Fall 2018 / Spring 2019 / Fall 2019
    Provides laboratory experience working on a bacteriophage genomics research project. Students will study novel bacteriophage they isolate from the environment. Topics covered include phage biology, bacteria and phage culturing and amplification, DNA isolation, restriction digest analysis, agarose gel electrophoresis, and electron microscopy.
  • MCDB 2150 - Principles of Genetics
    Primary Instructor - Fall 2018 / Fall 2019
    Introduces the behavior of genes and chromosomes in eukaryotic and prokaryotic organisms. Covers three areas: transmission genetics, molecular genetics, and population genetics. Attention is given to genetic mapping, recombinant DNA procedures, and gene expression. Recommended prerequisite: MCDB 1150 or EBIO 1210 or CHEN 2810 (minimum grade C-) and recommended corequisites of MCDB 2151 and MCDB 2152. Degree credit not granted for this course and MCDB 2222.
  • MCDB 2152 - Problem Solving Co-Seminars for Genetics
    Primary Instructor - Spring 2018 / Fall 2018 / Spring 2019 / Fall 2019
    Uses problem solving and other interactive group work to aid student learning in MCDB 2150. Students will work in small groups on learning and practicing how to solve difficult conceptual problems, as well as using hands-on activities and concept mapping to help learn content. Recommended corequisite: MCDB 2150.
  • MCDB 2161 - From DNA to Genes, Phage Genomics Laboratory II
    Primary Instructor - Spring 2018 / Fall 2018 / Spring 2019
    Provides laboratory experience working on a bacteriophage isolated during the previous semester. Topics include bioinformatics, genome annotation, open reading frame and RNA identification, BLAST analysis, phylogenetics and submission to a genomic database.
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.

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