Journal of Medicinal Chemistry Journal

Overview

publication venue for

• Structural Refinement of Glucagon for Therapeutic Use 2020
• Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists 2015
• Structure-Activity Relationship Studies of the Tricyclic Indoline Resistance-Modifying Agent 2014
• Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization 2013
• Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine 2012
• Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine 2009
• Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases 2008
• Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug 2008
• Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism 2007
• Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases 2006
• Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA 2005
• Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells 2004
• Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. 2004
• Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera 2004
• Design, synthesis, and biological evaluation of doxorubicin - Formaldehyde conjugates targeted to breast cancer cells 2004
• Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate 2003
• Epidoxoform: A hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells 1998
• Doxoform and daunoform: Anthracycline-formaldehyde conjugates toxic to resistant tumor cells 1997
• Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin 1997
• Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin 1996
• Inhibition of UDP-N-acetylglucosamine import into Golgi membranes by nucleoside monophosphates 1996
• WATER-SOLUBLE 3RD GENERATION ANTITUMOR PLATINUM COMPLEXES, [2,2-BIS(AMINOMETHYL)-1,3-PROPANEDIOL-N,N']-[1,1-CYCLOBUTANEDICARBOXYLATO(2-)-O,O']PLATINUM(II) AND [1,1-CYCLOBUTANEDICARBOXYLATO(2-)-O,O'][TETRAHYDRO-4H-PYRAN-4,4-DIMETHANAMINE-N,N']PLATINUM(II)3 1989

Research

keywords

• 0304 Medicinal and Biomolecular Chemistry, 1115 Pharmacology and Pharmaceutical Sciences, 0305 Organic Chemistry