Evidence that synaptic transmission between giant interneurons and identified thoracic interneurons in the cockroach is cholinergic. Journal Article uri icon

Overview

abstract

  • In the cockroach, a population of thoracic interneurons (TIs) receives direct inputs from a population of ventral giant interneurons (vGIs). Synaptic potentials in type-A TIs (TIAs) follow vGI action potentials with constant, short latencies at frequencies up to 200 Hz. These connections are important in the integration of directional wind information involved in determining an oriented escape response. The physiological and biochemical properties of these connections that underlie this decision-making process were examined. Injection of hyperpolarizing or depolarizing current into the postsynaptic TIAs resulted in alterations in the amplitude of the post-synaptic potential (PSP) appropriate for a chemical connection. In addition, bathing cells in zero-calcium, high-magnesium saline resulted in a gradual decrement of the PSP, and ultimately blocked synaptic transmission, reversibly. Single-cell choline acetyltransferase (ChAT) assays of vGI somata were performed. These assays indicated that the vGIs can synthesize acetylcholine. Furthermore, the pharmacological specificity of transmission at the vGI to TIA connections was similar to that previously reported for nicotinic, cholinergic synapses in insects, suggesting that the transmitter released by vGIs at these synapses is acetylcholine.

publication date

  • August 1, 1992

has subject area

Date in CU Experts

  • March 13, 2015 12:51 PM

Full Author List

  • Casagrand JL; Ritzmann RE

author count

  • 2

citation count

  • 7

Other Profiles

International Standard Serial Number (ISSN)

  • 0022-3034

Electronic International Standard Serial Number (EISSN)

  • 1097-4695

Additional Document Info

start page

  • 627

end page

  • 643

volume

  • 23

issue

  • 6