Endoplasmic reticulum structure and interconnections with other organelles. Journal Article uri icon

Overview

abstract

  • The endoplasmic reticulum (ER) is a large, continuous membrane-bound organelle comprised of functionally and structurally distinct domains including the nuclear envelope, peripheral tubular ER, peripheral cisternae, and numerous membrane contact sites at the plasma membrane, mitochondria, Golgi, endosomes, and peroxisomes. These domains are required for multiple cellular processes, including synthesis of proteins and lipids, calcium level regulation, and exchange of macromolecules with various organelles at ER-membrane contact sites. The ER maintains its unique overall structure regardless of dynamics or transfer at ER-organelle contacts. In this review, we describe the numerous factors that contribute to the structure of the ER.

publication date

  • April 1, 2013

Full Author List

  • English AR; Voeltz GK

Other Profiles

Additional Document Info

start page

  • a013227

volume

  • 5

issue

  • 4