- Previous research has shown that when right-handed subjects prefer one orientation of a picture over its mirror image, the more interesting or important content is on the right. Location of content, however, is only one of a number of possible asymmetric aspects of picture composition. To determine whether the relationship between aesthetic preference and cerebral asymmetry is affected by the interaction of different aspects of asymmetric information in a slide, the present study examined both asymmetry of content and asymmetry of motion. The results indicated that asymmetry of both content and motion combined to influence orientation preferences of right-but not left-handers. Thus, at least two asymmetric components of picture composition interact with brain organization to influence aesthetic judgements.