Membrane manipulations by the ESCRT machinery. Journal Article uri icon

Overview

abstract

  • The endosomal sorting complexes required for transport (ESCRTs) collectively comprise a machinery that was first known for its function in the degradation of transmembrane proteins in the endocytic pathway of eukaryotic cells. Since their discovery, however, ESCRTs have been recognized as playing important roles at the plasma membrane, which appears to be the original site of function for the ESCRT machinery. This article reviews some of the major research findings that have shaped our current understanding of how the ESCRT machinery controls membrane dynamics and considers new roles for the ESCRT machinery that might be driven by these mechanisms.

publication date

  • January 1, 2015

Full Author List

  • Odorizzi G

Other Profiles

Additional Document Info

start page

  • 516

volume

  • 4

issue

  • F1000 Faculty Rev