Membrane manipulations by the ESCRT machinery. Journal Article uri icon



  • The endosomal sorting complexes required for transport (ESCRTs) collectively comprise a machinery that was first known for its function in the degradation of transmembrane proteins in the endocytic pathway of eukaryotic cells. Since their discovery, however, ESCRTs have been recognized as playing important roles at the plasma membrane, which appears to be the original site of function for the ESCRT machinery. This article reviews some of the major research findings that have shaped our current understanding of how the ESCRT machinery controls membrane dynamics and considers new roles for the ESCRT machinery that might be driven by these mechanisms.

publication date

  • January 1, 2015

has restriction

  • gold

Date in CU Experts

  • September 10, 2015 7:57 AM

Full Author List

  • Odorizzi G

author count

  • 1

Other Profiles

International Standard Serial Number (ISSN)

  • 2046-1402

Additional Document Info

start page

  • 516


  • 4


  • F1000 Faculty Rev