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Publications in VIVO
 

Odorizzi, Greg Professor

Positions

Research Areas research areas

Research

research overview

  • My research investigates the molecular mechanisms of membrane trafficking from endosomes to lysosomes, which have a major role in protein degradation. Transmembrane proteins ubiquitinated on their cytoplasmic domains are sorted into vesicles that bud into the lumen of endosomes, resulting in their degradation upon fusion of endosomes with lysosomes. Molecular recognition of ubiquitinated transmembrane proteins requires an elaborate machinery known as the endosomal sorting complexes required for transport (ESCRTs). Defects in the ESCRT machinery make profound contributions to human disease. My research on ESCRTs uses the model system Saccharomyces cerevisiae and a combination of genetics, cell biology, biochemistry, and electron tomographic modeling of membrane structures.

keywords

  • membrane trafficking, membrane scission, membrane tethering, membrane fusion, protein ubiquitination, protein deubiquitination

Publications

selected publications

Teaching

courses taught

  • MCDB 2150 Principles of Genetics (Spring 2019)
  • MCDB 4840 Upper-Division Independent Study (Spring 2019)
  • MCDB 4980 Honors Research (Spring 2019)
  • MCDB 4990 Honors Thesis (Spring 2019)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • MCDB 4840 Upper-Division Independent Study (Fall 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Fall 2018)
  • MCDB 7840 Graduate Independent Study (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • MCDB 2840 Lower-Division Independent Study (Summer 2018)
  • MCDB 7840 Graduate Independent Study (Summer 2018)
  • MCDB 8990 Doctoral Dissertation (Summer 2018)
  • MCDB 2150 Principles of Genetics (Spring 2018)
  • MCDB 4840 Upper-Division Independent Study (Spring 2018)
  • MCDB 4980 Honors Research (Spring 2018)
  • MCDB 4990 Honors Thesis (Spring 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles