Structure and function of nucleosome assembly proteins. Journal Article uri icon



  • Homologues of nucleosome assembly protein 1 (NAP1) have been identified in all eukaryotes. Although initially identified as histone chaperones and chromatin-assembly factors, additional functions include roles in tissue-specific transcription regulation, apoptosis, histone shuttling, and cell-cycle regulation, and extend beyond those of a simple chaperone and assembly factor. NAP1 family members share a structurally conserved fold, the NAP domain. Here we review current knowledge of the NAP family of proteins within the context of the recently determined crystal structure of the NAP1 family's first representative, NAP1 from yeast.

publication date

  • August 1, 2006

has subject area

Full Author List

  • Park Y-J; Luger K

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Additional Document Info

start page

  • 549

end page

  • 558


  • 84


  • 4