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Luger, Karolin Professor, Jennie Smoly Caruthers Endowed Chair, and Howard Hughes Medical Institute Investigator

Positions

Research Areas research areas

Research

research overview

  • Research in the Luger Lab focuses on the structural biology of genome organization. We aim to understand the fundamental impact of chromatin architecture on genome-related processes such as regulated gene transcription, DNA replication, and DNA repair. We study the interaction of nucleosomes with nuclear factors, and structural and mechanistic aspects of the cellular machinery that assembles and disassembles chromatin during transcription, replication, and DNA repair. The evolution of eukaryotic chromatin structure is investigated through structural studies of archaeal chromatin. We use a wide range of approaches ranging from structural biology, biophysics, molecular and cell biology.

keywords

  • chromatin / nucleosome structure and function, protein-DNA interactions, DNA replication, DNA repair, DNA transcription, histone chaperones, nucleosome dynamics, x-ray crystallography, mass spectrometry, SAXS, fluorescence, atomic force microscopy, analytical ultra centrifugation, evolution, electron microscopy, Archaea

Publications

selected publications

Teaching

courses taught

  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2019)
  • CHEM 6901 Research in Chemistry (Spring 2019)
  • CHEM 8991 Doctoral Dissertation (Spring 2019)
  • CHEM 4720 Metabolic Pathways and Human Disease (Fall 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Fall 2018)
  • CHEM 5720 Metabolic Pathways and Human Disease (Fall 2018)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • CHEM 8991 Doctoral Dissertation (Fall 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Summer 2018)
  • CHEM 6901 Research in Chemistry (Summer 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2018)
  • CHEM 6901 Research in Chemistry (Spring 2018)
  • CHEM 8991 Doctoral Dissertation (Spring 2018)

Background

awards and honors

International Activities

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