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Luger, Karolin Professor, Jennie Smoly Caruthers Endowed Chair, and Howard Hughes Medical Institute Investigator

Positions

Research Areas research areas

Research

research overview

  • Research in the Luger Lab focuses on the structural biology of genome organization. We aim to understand the fundamental impact of chromatin architecture on genome-related processes such as regulated gene transcription, DNA replication, and DNA repair. We study the interaction of nucleosomes with nuclear factors, and structural and mechanistic aspects of the cellular machinery that assembles and disassembles chromatin during transcription, replication, and DNA repair. The evolution of eukaryotic chromatin structure is investigated through structural studies of archaeal chromatin. We use a wide range of approaches ranging from structural biology, biophysics, molecular and cell biology.

keywords

  • chromatin / nucleosome structure and function, protein-DNA interactions, DNA replication, DNA repair, DNA transcription, histone chaperones, nucleosome dynamics, x-ray crystallography, mass spectrometry, SAXS, fluorescence, atomic force microscopy, analytical ultra centrifugation, evolution, electron microscopy, Archaea

Publications

selected publications

Teaching

courses taught

  • BCHM 4720 - Metabolic Pathways and Human Disease
    Primary Instructor - Fall 2018
    Covers energy metabolism and anabolic/catabolic pathways; metabolism of carbohydrates, lipids, amino acids, and nucleic acids; photosynthesis; special topics on human diseases with pathologies and metabolic pathways. Formerly CHEM 4720. Same as BCHM 5720.
  • BCHM 5720 - Metabolic Pathways and Human Disease
    Primary Instructor - Fall 2018
    Covers energy metabolism and anabolic/catabolic pathways; metabolism of carbohydrates, lipids, amino acids, and nucleic acids; photosynthesis; special topics on human diseases with pathologies and metabolic pathways. Formerly CHEM 5720. Same as BCHM 4720.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
    May be repeated up to 15 total credit hours.

Background

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