Structure and dynamic properties of nucleosome core particles. Journal Article uri icon

Overview

abstract

  • It is now widely recognized that the packaging of genomic DNA, together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, DNA repair, and recombination. Whereas earlier structural studies portrayed nucleosomes (the basic repeating unit of chromatin) as monolithic and static macromolecular assemblies, we now know that they are highly dynamic and capable of extensive crosstalk with the cellular machinery. Histone variants have evolved to locally alter chromatin structure, whereas histone chaperones and other cellular factors promote histone exchange and chromatin fluidity. Both of these phenomena likely facilitate interconversion between different chromatin states that show varying degrees of transcriptional activity.

publication date

  • February 7, 2005

Full Author List

  • Chakravarthy S; Park Y-J; Chodaparambil J; Edayathumangalam RS; Luger K

Other Profiles

Additional Document Info

start page

  • 895

end page

  • 898

volume

  • 579

issue

  • 4