In situ AFM analysis investigating disassembly of DNA nanoparticles and nano-films. Journal Article uri icon

Overview

abstract

  • Synthetic vector-based gene delivery systems continue to gain strength as viable alternatives to viral vectors due to safety and other concerns. DNA release dynamics is key to the understanding and control of gene delivery from nano-systems. Here we describe atomic force microscope application to the understanding of DNA release dynamics from bioreducible polycation-based nano-systems. The two nano-systems are polyplex nanoparticles and layer-by-layer films.

publication date

  • January 1, 2013

Full Author List

  • Zou Y; Wan L; Blacklock J; Oupicky D; Mao G

Other Profiles

Additional Document Info

start page

  • 183

end page

  • 193

volume

  • 948