The Influence of Oxygen Saturation on the Relationship Between Hemoglobin Mass and VO 2 max. Journal Article uri icon



  • Hemoglobin mass (tHb) is a key determinant of maximal oxygen uptake (VO 2 max). We examined whether oxyhemoglobin desaturation (ΔS a O 2 ) at VO 2 max modifies the relationship between tHb and VO 2 max at moderate altitude (1,625 m). Seventeen female and 16 male competitive, endurance-trained moderate-altitude residents performed two tHb assessments and two graded exercise tests on a cycle ergometer to determine VO 2 max and ΔS a O 2 . In males and females respectively, VO 2 max (ml·kg -1 ·min -1 ) ranged from 62.5-83.0 and 44.5-67.3; tHb (g·kg -1 ) ranged from 12.1-17.5 and 9.1-13.0; and S a O 2 at VO 2 max (%) ranged from 81.7-94.0 and 85.7-95.0. tHb was related to VO 2 max when expressed in absolute terms and after correcting for body mass (r=0.94 and 0.86, respectively); correcting by ΔS a O 2 did not improve these relationships (r=0.93 and 0.83). Additionally, there was a negative relationship between tHb and S a O 2 at VO 2 max (r=-0.57). In conclusion, across a range of endurance athletes at moderate altitude, the relationship between tHb and VO 2 max was found to be similar to that observed at sea level. However, correcting tHb by ΔS a O 2 did not explain additional variability in VO 2 max despite significant variability in ΔS a O 2 ; this raises the possibility that tHb and exercise-induced ΔS a O 2 are not independent in endurance athletes.

publication date

  • July 1, 2018

has restriction

  • gold

Date in CU Experts

  • December 19, 2018 6:27 AM

Full Author List

  • Goodrich JA; Ryan BJ; Byrnes WC

author count

  • 3

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 2367-1890

Additional Document Info

start page

  • E98

end page

  • E104


  • 2


  • 4