Geographic Clustering of Polygenic Scores at Different Stages of the Life Course. Journal Article uri icon

Overview

abstract

  • We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individual's educational attainment net of that person's polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research.

publication date

  • April 1, 2018

Full Author List

  • Domingue BW; Rehkopf DH; Conley D; Boardman JD

Other Profiles

Additional Document Info

start page

  • 137

end page

  • 149

volume

  • 4

issue

  • 4