The characterization of protein post-translational modifications by mass spectrometry. Journal Article uri icon

Overview

abstract

  • Most biological processes are regulated by post-translational modifications of proteins, and conditions that disrupt the regulation of such events can lead to disease. In the past decade, the identification and characterization of covalent modifications have been driven by advances in mass spectrometry. Here, we discuss current mass spectrometric and proteomic approaches for the identification of proteins and their covalent modifications, and we highlight high-throughput strategies for comprehensive analysis of cell proteomes.

publication date

  • June 1, 2003

Full Author List

  • Schweppe RE; Haydon CE; Lewis TS; Resing KA; Ahn NG

Other Profiles

Additional Document Info

start page

  • 453

end page

  • 461

volume

  • 36

issue

  • 6