Research Interests: Signal transduction pathways in melanoma, MAP kinase pathways and mechanisms of response to targeted therapeutics against BRaf, MAPKK, and MAP kinases, and drug resistance in cancer cells. Control of cancer cell polarity and migration by Wnt5a pathway signaling. Analysis of protein kinase regulation with studies of protein dynamics by hydrogen exchange mass spectrometry, NMR, enzyme kinetics and site directed mutagenesis. Analysis of signaling responses by functional proteomics, and methods development for proteomics and mass spectrometry.
Signal transduction pathways in cancer, Melanoma mechanisms of drug resistance, Functional proteomics, mass spectrometry, bioanalytical studies of proteins, protein chemistry
BCHM 4761 - Biochemistry Laboratory
Two 4-hour periods per week. Introduction to modern biochemical techniques. Topics include enzymology, spectrophotometry, electrophoresis, multi-step protein purification, recombinant DNA techniques and molecular cloning. Formerly CHEM 4761.
CHEM 1400 - Foundations of Chemistry
Covers core concepts in chemistry: nature of matter (atomic and molecular structure, bonding and macroscopic properties), transformations of matter (chemical reactivity), and quantifying chemical transformations (thermochemistry, thermodynamics and kinetics). Emphasizes critical thinking and cultivate core problem solving skills utilized by scientists. Intended for first semester CHEM/BCHM majors. Department enforced prerequisites: one year high school chemistry or CHEM 1021 (minimum grad C-) and high school math through pre-calculus. Not recommended for students with grades below B- in CHEM 1021. Department enforced corequisite: CHEM 1401. Credit not granted for this course and CHEM 1113. Formerly CHEM 1251.
CHEM 6901 - Research in Chemistry
Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
May be repeated up to 15 total credit hours.