Research Interests: Signal transduction pathways in melanoma, MAP kinase pathways and mechanisms of response to targeted therapeutics against BRaf, MAPKK, and MAP kinases, and drug resistance in cancer cells. Control of cancer cell polarity and migration by Wnt5a pathway signaling. Analysis of protein kinase regulation with studies of protein dynamics by hydrogen exchange mass spectrometry, NMR, enzyme kinetics and site directed mutagenesis. Analysis of signaling responses by functional proteomics, and methods development for proteomics and mass spectrometry.
keywords
Signal transduction pathways in cancer, Melanoma mechanisms of drug resistance, Functional proteomics, mass spectrometry, bioanalytical studies of proteins, protein chemistry
BCHM 4720 - Metabolic Pathways and Human Disease
Primary Instructor
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Spring 2023 / Spring 2024
Covers energy metabolism and anabolic/catabolic pathways; metabolism of carbohydrates, lipids, amino acids, and nucleic acids; photosynthesis; special topics on human diseases with pathologies and metabolic pathways. Formerly CHEM 4720. Same as BCHM 5720.
BCHM 6901 - Research in Biochemistry
Primary Instructor
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Fall 2021 / Spring 2022 / Fall 2022 / Spring 2023
May be repeated up to 15 total credit hours.
CHEM 1400 - Foundations of Chemistry
Primary Instructor
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Fall 2019 / Fall 2020 / Fall 2021
Covers core concepts in chemistry: nature of matter (atomic and molecular structure, bonding and macroscopic properties), transformations of matter (chemical reactivity), and quantifying chemical transformations (thermochemistry, thermodynamics and kinetics). Emphasizes critical thinking and cultivate core problem solving skills utilized by scientists. Intended for first semester CHEM/BCHM majors. Department enforced prerequisites: one year high school chemistry or CHEM 1021 (minimum grad C-) and high school math through pre-calculus. Not recommended for students with grades below B- in CHEM 1021. Department enforced corequisite: CHEM 1401. Degree credit not granted for this course and CHEM 1113.
CHEM 4761 - Biochemistry Laboratory
Primary Instructor
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Fall 2018
Two 4-hour periods per week. Introduction to modern biochemical techniques. Topics include enzymology, spectrophotometry, electrophoresis, multi-step protein purification, recombinant DNA techniques and molecular cloning. Formerly CHEM 4761.
