Research Interests: Signal transduction pathways in melanoma, MAP kinase pathways and mechanisms of response to targeted therapeutics against BRaf, MAPKK, and MAP kinases, and drug resistance in cancer cells. Control of cancer cell polarity and migration by Wnt5a pathway signaling. Analysis of protein kinase regulation with studies of protein dynamics by hydrogen exchange mass spectrometry, NMR, enzyme kinetics and site directed mutagenesis. Analysis of signaling responses by functional proteomics, and methods development for proteomics and mass spectrometry.
Signal transduction pathways in cancer, Melanoma mechanisms of drug resistance, Functional proteomics, mass spectrometry, bioanalytical studies of proteins, protein chemistry