A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy. Journal Article uri icon



  • PGC-1alpha is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise but has no effectson muscle strength or hypertrophy. We have identified a form of PGC-1alpha (PGC-1alpha4) that results from alternative promoter usage and splicing of the primary transcript. PGC-1alpha4 is highly expressed in exercised muscle but doesnot regulate most known PGC-1alpha targets such as the mitochondrial OXPHOS genes. Rather, it specifically induces IGF1 and represses myostatin, and expression of PGC-1alpha4 in vitro and in vivo induces robust skeletal muscle hypertrophy. Importantly, mice with skeletal muscle-specific transgenic expression of PGC-1alpha4 show increased muscle mass and strength and dramatic resistance to the muscle wasting of cancer cachexia. Expression of PGC-1alpha4 is preferentially induced in mouse and human muscle during resistance exercise. These studies identify a PGC-1alpha protein that regulates and coordinates factors involved in skeletal muscle hypertrophy.

publication date

  • December 7, 2012

Date in CU Experts

  • October 1, 2013 11:33 AM

Full Author List

  • Ruas JL; White JP; Rao RR; Kleiner S; Brannan KT; Harrison BC; Greene NP; Wu J; Estall JL; Irving BA

author count

  • 17

published in

Additional Document Info

start page

  • 1319-31

end page

  • 1319-31


  • 151


  • 6