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Publications in VIVO
 

Leinwand, Leslie Anne Distinguished Professor

Positions

Research Areas research areas

Research

research overview

  • We conduct research on cardiac and skeletal muscle with emphasis on genetic diseases involving them. We found that diet has the most potent effect on mouse hearts of any stimulus we have studied. Males exercise less than females in response to a given amount of exercise when both genders are fed soy but not when both are fed casein. We are exploring how soy estrogens regulate cardiac growth. We have determined the role of estrogen receptors in these phytoestrogen-mediated events. We have recently documented strong interdependence of cardiac and skeletal muscle adaptation and are doing experiments to define the molecular mechanisms of such cross-talk. Finally, we established a model of extreme physiologic cardiac growth and regression in the Burmese python where hearts double in size within 48 hours following a meal and then regress to pre-feeding size just as quickly. A factor in the serum of the post-fed python induces cellular hypertrophy in rat cardiac cells.

keywords

  • molecular biology, cardiovascular research, human genetic disease, biophysics, myosin, motor proteins, miRNAs, muscular dystrophy, gender biology, metabolism

Publications

selected publications

Teaching

courses taught

  • CHEM 6901 Research in Chemistry (Spring 2019)
  • MCDB 4990 Honors Thesis (Spring 2019)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2019)
  • MCDB 7840 Graduate Independent Study (Spring 2019)
  • MCDB 8990 Doctoral Dissertation (Spring 2019)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • CHEM 8991 Doctoral Dissertation (Fall 2018)
  • MCDB 4840 Upper-Division Independent Study (Fall 2018)
  • MCDB 4980 Honors Research (Fall 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Fall 2018)
  • MCDB 8990 Doctoral Dissertation (Fall 2018)
  • MCDB 4840 Upper-Division Independent Study (Summer 2018)
  • MCDB 8990 Doctoral Dissertation (Summer 2018)
  • CHEM 6901 Research in Chemistry (Spring 2018)
  • MCDB 4990 Honors Thesis (Spring 2018)
  • MCDB 6000 Introduction to Laboratory Methods (Spring 2018)
  • MCDB 7840 Graduate Independent Study (Spring 2018)
  • MCDB 8990 Doctoral Dissertation (Spring 2018)

Background

awards and honors

International Activities

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