journal article

• The structure of human CST reveals a decameric assembly bound to telomeric DNA.  Science. 1081-+. 2020
  
• The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA 2019
  
• A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.  Genome Biology. 2015
  
• TERT promoter mutations and telomerase reactivation in urothelial cancer.  Science. 1006-1010. 2015
  
• Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.  Journal of Cell Science. 331-341. 2015
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.  Nucleic Acids Research. 8969-8978. 2013

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.  Nature. 285-+. 2012

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.  Nature. 399-+. 2011

Functional interaction between telomere protein TPP1 and telomerase.  Genes and Development. 613-622. 2010

Mutation in TERT separates processivity from anchor-site function.  Nature Structural and Molecular Biology. 871-872. 2008
The POT1-TPP1 telomere complex is a telomerase processivity factor.  Nature. 506-510. 2007

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.  Proceedings of the National Academy of Sciences of USA. 10864-10869. 2005

Switching human telomerase on and off with hPOT1 protein in vitro.  Journal of Biological Chemistry. 20449-20456. 2005

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.  RNA. 1323-1332. 2003

Yeast telomerase is specialized for C/A-rich RNA templates.  Nucleic Acids Research. 1646-1655. 2003
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction..  Molecular and Cellular Biology. 2366-2374. 2002
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.  Nature. 177-180. 1999

Polyadenylation of telomerase RNA in budding yeast.  RNA. 1337-1351. 1997
Method for determining RNA 3' ends and application to human telomerase RNA.  Nucleic Acids Research. 532-533. 1996

RELATIVE ORIENTATION OF RNA HELICES IN A GROUP-I RIBOZYME DETERMINED BY HELIX EXTENSION ELECTRON-MICROSCOPY.  The EMBO Journal. 4849-4859. 1995
ANALYSIS OF THE STRUCTURE OF TETRAHYMENA NUCLEAR RNAS IN-VIVO - TELOMERASE RNA, THE SELF-SPLICING RIBOSOMAL-RNA INTRON, AND U2 SNRNA.  RNA. 363-374. 1995
CATALYSIS OF RNA CLEAVAGE BY A RIBOZYME DERIVED FROM THE GROUP-I INTRON OF ANABAENA PRE-TRNA(LEU).  Biochemistry. 14935-14947. 1994

SELF-SPLICING OF THE GROUP-I INTRON FROM ANABAENA PRE-TRANSFER-RNA - REQUIREMENT FOR BASE-PAIRING OF THE EXONS IN THE ANTICODON STEM.  Biochemistry. 7946-7953. 1993

AMINOACYL ESTERASE-ACTIVITY OF THE TETRAHYMENA RIBOZYME.  Science. 1420-1424. 1992

The intervening sequence RNA of Tetrahymena is an enzyme. 1986..  Biotechnology (Reading, Mass.). 57-62. 1992
SELF-SPLICING AND ENZYMATIC CLEAVAGE OF RNA BY A GROUP-I INTERVENING SEQUENCE.  Methods in Enzymology. 558-568. 1990
SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME - ENHANCED CLEAVAGE OF CERTAIN OLIGONUCLEOTIDE SUBSTRATES THAT FORM MISMATCHED RIBOZYME SUBSTRATE COMPLEXES.  Biochemistry. 8924-8931. 1988

SELF-SPLICING RNA AND AN RNA ENZYME IN TETRAHYMENA.  The Journal of protozoology. 416-417. 1987
STRUCTURES INVOLVED IN TETRAHYMENA RIBOSOMAL-RNA SELF-SPLICING AND RNA ENZYME-ACTIVITY.  Cold Spring Harbor Laboratory: Symposia on Quantitative Biology. 147-157. 1987
THE TETRAHYMENA RIBOZYME ACTS LIKE AN RNA RESTRICTION ENDONUCLEASE.  Nature. 429-433. 1986

THE TETRAHYMENA INTERVENING SEQUENCE RIBONUCLEIC-ACID ENZYME IS A PHOSPHOTRANSFERASE AND AN ACID-PHOSPHATASE.  Biochemistry. 4478-4482. 1986

ROLE OF CONSERVED SEQUENCE ELEMENT-9L AND ELEMENT-2 IN SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL-RNA PRECURSOR.  Cell. 167-176. 1986

THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME.  Science. 470-475. 1986

OLIGOMERIZATION OF INTERVENING SEQUENCE RNA MOLECULES IN THE ABSENCE OF PROTEINS.  Science. 1060-1064. 1985

REACTIONS OF THE INTERVENING SEQUENCE OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR - PH-DEPENDENCE OF CYCLIZATION AND SITE-SPECIFIC HYDROLYSIS.  Biochemistry. 6211-6218. 1985

A LABILE PHOSPHODIESTER BOND AT THE LIGATION JUNCTION IN A CIRCULAR INTERVENING SEQUENCE RNA.  Science. 574-578. 1984

AUTOCATALYTIC CYCLIZATION OF AN EXCISED INTERVENING SEQUENCE RNA IS A CLEAVAGE LIGATION REACTION.  Nature. 578-583. 1983

SELF-SPLICING RNA - AUTO-EXCISION AND AUTO-CYCLIZATION OF THE RIBOSOMAL-RNA INTERVENING SEQUENCE OF TETRAHYMENA.  Cell. 147-157. 1982

THE INTERVENING SEQUENCE EXCISED FROM THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA CONTAINS A 5'-TERMINAL GUANOSINE RESIDUE NOT ENCODED BY THE DNA.  Nucleic Acids Research. 2823-2838. 1982

INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.  Cell. 487-496. 1981

THE INTERVENING SEQUENCE OF THE RIBOSOMAL-RNA PRECURSOR IS CONVERTED TO A CIRCULAR RNA IN ISOLATED-NUCLEI OF TETRAHYMENA.  Cell. 467-476. 1981

INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR IN NUCLEI OF TETRAHYMENA.  Cell. 331-338. 1980

Bohr effect in Escherichia coli aspartate transcarbamylase. Linkages between substrate binding, proton binding, and conformational transitions..  Biochemistry. 3008-3015. 1979
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