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Sousa, Marcelo Carlos Professor

Positions

Research Areas research areas

Research

research overview

  • Dr. Sousa uses a multidisciplinary research approach, with X-ray crystallography to obtain high-resolution structures and complementary biochemical and biophysical studies to understand, in molecular detail, cellular processes including: (i) Bacterial and Mitochondrial Outer Membrane Biogenesis: focused on how chaperones and the BAM membrane protein complex cooperate to promote folding and specific insertion of beta-barrel OMPs into bacterial and mitochondrial outer membranes. (ii) Modification of the Bacterial Outer Membranes Mediating Antibiotic Resistance: Lipid-A modification with Ara4N confers resistance to antibiotics such as colistin. Dr. Sousa‚Äôs group determines the structure and mechanism of enzymes essential for this modification as a key for the design of specific inhibitors of antibiotic resistance. (iii) Protein Secretion Systems: Focused on understanding for bacterial protein secretion and its repurposing for delivery of engineered proteins to the host.

keywords

  • Structural Biology

Publications

selected publications

Teaching

courses taught

  • BCHM 5770 - Fundamentals of Biochemistry I
    Primary Instructor - Fall 2018
    Analysis of topics in biochemistry including DNA structure and replication, RNA synthesis and processing, protein synthesis, enzyme function and mechanism, and protein structure and dynamics. Intended as a comprehensive treatment of areas central to modern biochemistry for entering graduate students. Lectures concurrent with BCHM 5771 covering the same topics except for the requirement of a written research proposal. Formerly CHEM 5770.
  • BCHM 5771 - Advanced General Biochemistry 1
    Primary Instructor - Fall 2018
    Lect. In-depth analysis of DNA structure and replication, RNA synthesis and processing, protein synthesis, enzyme function and mechanism, protein structure, protein dynamics, and physical chemistry of macromolecules. Intended as a comprehensive treatment of areas central to modern biochemistry for entering graduate students. Formerly CHEM 5771.
  • BCHM 5776 - Scientific Ethics and Responsible Conduct in Research
    Primary Instructor - Fall 2018
    Lect. Advanced discussion of topics in scientific ethics, including requirements for responsible conduct of research, case histories of fraud, research misconduct, ethical misconduct and development of professional values and ethical standards. Same as MCDB 5776.
  • CHEM 6901 - Research in Chemistry
    Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
    May be repeated up to 15 total credit hours.
  • MCDB 5776 - Scientific Ethics and Responsible Conduct in Research
    Primary Instructor - Fall 2019
    Lect. Advanced discussion of topics in scientific ethics, including requirements for responsible conduct of research, case histories of fraud, research misconduct, ethical misconduct and development of professional values and ethical standards. Same as BCHM 5776.

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