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Publications in VIVO
 

Sousa, Marcelo Carlos Professor

Positions

Research Areas research areas

Research

research overview

  • Dr. Sousa uses a multidisciplinary research approach, with X-ray crystallography to obtain high-resolution structures and complementary biochemical and biophysical studies to understand, in molecular detail, cellular processes including: (i) Bacterial and Mitochondrial Outer Membrane Biogenesis: focused on how chaperones and the BAM membrane protein complex cooperate to promote folding and specific insertion of beta-barrel OMPs into bacterial and mitochondrial outer membranes. (ii) Modification of the Bacterial Outer Membranes Mediating Antibiotic Resistance: Lipid-A modification with Ara4N confers resistance to antibiotics such as colistin. Dr. Sousa‚Äôs group determines the structure and mechanism of enzymes essential for this modification as a key for the design of specific inhibitors of antibiotic resistance. (iii) Protein Secretion Systems: Focused on understanding for bacterial protein secretion and its repurposing for delivery of engineered proteins to the host.

keywords

  • Structural Biology

Publications

selected publications

Teaching

courses taught

  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2019)
  • CHEM 6901 Research in Chemistry (Spring 2019)
  • CHEM 8991 Doctoral Dissertation (Spring 2019)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Fall 2018)
  • CHEM 5770 Fundamentals of Biochemistry I (Fall 2018)
  • CHEM 5771 Advanced General Biochemistry 1 (Fall 2018)
  • CHEM 5776 Scientific Ethics and Responsible Conduct in Research (Fall 2018)
  • CHEM 6901 Research in Chemistry (Fall 2018)
  • CHEM 8991 Doctoral Dissertation (Fall 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Summer 2018)
  • CHEM 6901 Research in Chemistry (Summer 2018)
  • CHEM 8991 Doctoral Dissertation (Summer 2018)
  • CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2018)
  • CHEM 6901 Research in Chemistry (Spring 2018)
  • CHEM 8991 Doctoral Dissertation (Spring 2018)

Background

International Activities

global connections related to teaching and scholarly work (in recent years)

Other Profiles