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Park, Soyeon Assistant Professor

Positions

Research Areas research areas

Research

research overview

  • Dr. Park's laboratory studies the biogenesis of a molecular machine known as the proteasome, a major protease in eukaryotes. Her studies have changed the traditional view of the spontaneous formation of the proteasomal ATPase ring, via revealing conserved novel assembly chaperones for regulating assembly of the heterohexameric ATPase complex of the proteasome. These four chaperones (Rpn14, Nas6, Hsm3, and Nas2) principally act as negative regulators of proteasome assembly, by coupling with ATP hydrolysis. Her laboratory focuses on elucidating; (i) biological functions of active dissociation via these chaperones, (ii) mechanisms of an assembly-coupled degradation via an oncorpotein and assembly chaperone, Gankyrin in cancers, and (iii) signaling pathways for active disassembly of the proteasome via the chaperones during stress. Her work will provide major insights into the fundamental regulatory mechanisms for the proteasome and controlled protein degradation.

keywords

  • Mechanisms of molecular chaperones, controlled protein degradation, ubiquitin-proteasome pathway

Publications

selected publications

Teaching

courses taught

  • MCDB 3135 - Molecular Cell Biology I
    Primary Instructor - Fall 2018
    Examines the central dogma of biology by discussing the most important molecules in cells (DNA, RNA and protein) and how their synthesis (DNA replication, transcription, RNA processing and translation) is regulated. Incorporated into the discussion is how recombinant DNA techniques are used to discover and dissect cellular processes, how to design and interpret experiments, and understanding the limits of experiments to draw conclusions. These principles are the foundation for subsequent examination of intracellular mechanisms in MCDB 3145.
  • MCDB 4980 - Honors Research
    Primary Instructor - Fall 2019
    Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
  • MCDB 4990 - Honors Thesis
    Primary Instructor - Fall 2019
    Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
  • MCDB 6000 - Introduction to Laboratory Methods
    Primary Instructor - Spring 2018 / Spring 2019
    Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.

Background

International Activities

global connections related to teaching and scholarly work (in recent years)