Research in the Chuong lab focuses on gene regulatory networks, which orchestrate complex biological functions. Changes to regulatory networks have major consequences for both organismal evolution and disease, but how such changes happen at the genomic level is not well understood. A central goal of the Chuong lab is to study the mechanisms and principles underlying regulatory network 'rewiring' as it occurs across species, individuals, and even cells. Research in the Chuong lab is highly interdisciplinary and relies heavily on both large-scale computational analyses and hypothesis-driven experiments in mammalian cells. The lab's ultimate goal is to advance our basic understanding of genome function and evolution, and provide new insights into the evolutionary basis of human diseases.
keywords
Transposons and gene regulation, genome evolution, functional genomics
MCDB 4520 - Bioinformatics and Genomics
Primary Instructor
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Spring 2020 / Spring 2021 / Fall 2021 / Fall 2022 / Fall 2023
Computational and experimental methods in bioinformatics and genomics, and how these methods provide insights into protein structure and function, molecular evolution, biological diversity, cell biology and human disease. Topics include database searching, multiple sequence alignment, molecular phylogeny, microarrays, proteomics and pharmacogenomics. Recommended prerequisites: MCDB 3135 or CHEM 4700 (minimum grade C-). Same as MCDB 5520.
MCDB 4990 - Honors Thesis
Primary Instructor
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Fall 2022
Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
MCDB 5520 - Bioinformatics and Genomics
Primary Instructor
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Spring 2020 / Spring 2021 / Fall 2021 / Fall 2022 / Fall 2023
Computational and experimental methods in bioinformatics and genomics, and how these methods provide insights into protein structure and function, molecular evolution, biological diversity, cell biology and human disease. Topics include database searching, multiple sequence alignment, molecular phylogeny, microarrays, proteomics and pharmacogenomics. Same as MCDB 4520.
MCDB 6000 - Introduction to Laboratory Methods
Primary Instructor
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Spring 2019 / Spring 2020 / Fall 2020 / Fall 2021 / Spring 2022 / Spring 2024 / Fall 2024
Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. May be repeated up to 15 total credit hours.
