Research in the Chuong lab focuses on gene regulatory networks, which orchestrate complex biological functions. Changes to regulatory networks have major consequences for both organismal evolution and disease, but how such changes happen at the genomic level is not well understood. A central goal of the Chuong lab is to study the mechanisms and principles underlying regulatory network 'rewiring' as it occurs across species, individuals, and even cells. Research in the Chuong lab is highly interdisciplinary and relies heavily on both large-scale computational analyses and hypothesis-driven experiments in mammalian cells. The lab's ultimate goal is to advance our basic understanding of genome function and evolution, and provide new insights into the evolutionary basis of human diseases.
Transposons and gene regulation, genome evolution, functional genomics
MCDB 4980 - Honors Research
Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
MCDB 4990 - Honors Thesis
Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee.
MCDB 6000 - Introduction to Laboratory Methods
Introduces methodology and techniques used in biological research. Designed as a tutorial between a few students and one faculty member. Students are expected to read original research papers, discuss findings, and to plan and execute experiments in selected areas. Open only to MCDB graduate students. May be repeated up to 9 total credit hours.