- Research in the Chuong lab focuses on gene regulatory networks, which orchestrate complex biological functions. Changes to regulatory networks have major consequences for both organismal evolution and disease, but how such changes happen at the genomic level is not well understood. A central goal of the Chuong lab is to study the mechanisms and principles underlying regulatory network 'rewiring' as it occurs across species, individuals, and even cells. Research in the Chuong lab is highly interdisciplinary and relies heavily on both large-scale computational analyses and hypothesis-driven experiments in mammalian cells. The lab's ultimate goal is to advance our basic understanding of genome function and evolution, and provide new insights into the evolutionary basis of human diseases.