Therapies targeting bone-degrading cells are the current standard of care for combating cancer metastasis in the skeleton. These cells are directed by cancer cells to degrade bone in order to release pro-tumorigenic growth factors stored within the skeletal extracellular matrix. These therapies are not curative and do not halt metastasis-mediated bone degradation, indicating additional factors contribute to bone degradation. My research program focuses on the skeletal mechanical environment and its role in cancer regulation. Specifically, I investigate 1) mechanoregulation of bone metastatic cancer cells, and 2) the role of bone-forming osteoblastic cells, which comprise the principal sensor and effector cells of mechanical cues, in metastatic processes. My experimental approach uses novel in vivo and in vitro mechanical loading model systems to correlate cellular function with tissue-level changes in tumor burden and skeletal tissue strength.
biomechanics, mechanobiology, cancer, bone, mechanical loading, 3D models
COEN 1550 - YOU'RE@CU: Undergraduate Career Seminar
Fall 2019 / Spring 2020
Exposes first or second year undergraduate students to engineering research careers through a partner program (YOU'RE@CU), panel discussions with researchers in academics and industry, and exposure to research labs. Restricted to YOU'RE@CU participants. Department consent required.
MCEN 2023 - Statics and Structures
Covers statics of particles, equivalent force systems, rigid bodies, equilibrium of rigid bodies in two and three dimensions, analysis of truss and frame structures, uniaxially-loaded members, distributed force systems and friction. Degree credit not granted for this course and CVEN 2121 or GEEN 2851.
MCEN 4085 - Mechanical Engineering Design Project 2
Second part of a two-course capstone design experience in mechanical engineering. Includes refinement of prototype, design optimization, fabrication, testing, and evaluation. Students orally present the final design and prepare a written report and operation manual for the product. GEEN-BS and GEEN-BSEPL students are not required to complete MCEN 4026.