Neural networks for determining protein specificity and multiple alignment of binding sites. Journal Article uri icon

Overview

abstract

  • We use a quantitative definition of specificity to develop a neural network for the identification of common protein binding sites in a collection of unaligned DNA fragments. We demonstrate the equivalence of the method to maximizing Information Content of the aligned sites when simple models of the binding energy and the genome are employed. The network method subsumes those simple models and is capable of working with more complicated ones. This is demonstrated using a Markov model of the E. coli genome and a sampling method to approximate the partition function. A variation of Gibbs' sampling aids in avoiding local minima.

publication date

  • January 1, 1994

has subject area

Date in CU Experts

  • March 13, 2015 11:20 AM

Full Author List

  • Heumann JM; Lapedes AS; Stormo GD

author count

  • 3

citation count

  • 5

Other Profiles

International Standard Serial Number (ISSN)

  • 1553-0833

Additional Document Info

start page

  • 188

end page

  • 194

volume

  • 2