Multistate reweighting and configuration mapping together accelerate the efficiency of thermodynamic calculations as a function of molecular geometry by orders of magnitude. Journal Article uri icon



  • We present an approach to calculate free energy and other thermodynamic property differences between molecules which have very little or no overlap in configuration space, but where a one-to-one mapping between the molecule geometries exists. The approach combines multistate reweighting with remapping of phase space between simulated states. We apply this method to calculate the free energy differences between non-overlapping, truncated harmonic oscillators, the free energy, enthalpy, and entropy differences between different parameterizations of rigid water, and differences in free energy of solvation between dipoles of different lengths. Previously difficult or impossible problems become either trivially easy or are improved in efficiency by two to five orders of magnitude.

publication date

  • April 21, 2013

has restriction

  • closed

Date in CU Experts

  • September 4, 2015 2:15 AM

Full Author List

  • Paliwal H; Shirts MR

author count

  • 2

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 1089-7690

Additional Document Info

start page

  • 154108


  • 138


  • 15