Evidence that brief stress may induce the acute phase response in rats. Journal Article uri icon

Overview

abstract

  • Exposing rats to a single session of inescapable tail shock (IS) reduces corticosteroid binding globulin (CBG) 24 h later (Fleshner et al., Endocrinology 136: 5336-5342, 1995). The present experiments examined whether reductions in CBG are differentially affected by controllable vs. identical uncontrollable tail shock, are mediated by IS-induced glucocorticoid elevation, or reflect IS-induced activation of the acute phase response and whether IS produces fever. The results demonstrate that 1) equivalent reductions in CBG are observed in response to escapable tail shock or yoked IS, 2) IS-induced CBG reduction is not blocked by adrenalectomy in rats that receive basal corticosteroid replacement or by pretreatment with RU-38486, and 3) IS appears to activate the acute phase response, since IS reduces serum levels of an acute-phase negative reactant (CBG), increases serum levels of acute-phase positive reactants (haptoglobin and alpha 1-acid glycoprotein), and increases core body temperature 20-24 h later.

publication date

  • December 1, 1997

Full Author List

  • Deak T; Meriwether JL; Fleshner M; Spencer RL; Abouhamze A; Moldawer LL; Grahn RE; Watkins LR; Maier SF

Additional Document Info

start page

  • R1998

end page

  • R2004

volume

  • 273

issue

  • 6 Pt 2