Grand Challenges are ambitious yet specific goals to galvanize a scholarly community for focused research and high impact. We solicited contributions from ten leading thinkers in the field of Engineering Project Organization (EPO) to elicit their visions for EPO research. Based on content analysis of the text in these statements, and analytical concept mapping, we created a Grand Challenges synthesis framework to set the stage for the future of EPO research. This technical paper describes the six Grand Challenges and associated research thrusts that could define the future of scholarship and impact in the field. The paper also reflects on recent contributions to the field and identifies both barriers and community aspirations to addressing the Grand Challenges.