Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation Journal Article uri icon



  • Significance; The relationship between long-range Polycomb-associated chromatin contacts and the linear propagation of histone H3 lysine 27 trimethylation (H3K27me3) by Polycomb repressive complex 2 (PRC2) is not well-characterized. Here, we nominate a role for developmental loci as genomic architectural elements that enable long-range spreading of H3K27me3. Polycomb-associated loops are disrupted upon loss of PRC2 binding and deletion of loop anchors results in alterations of H3K27me3 deposition and ectopic gene expression. These results suggest that Polycomb-mediated genome architecture is important for gene repression during embryonic development.

publication date

  • May 31, 2022

has restriction

  • hybrid

Date in CU Experts

  • June 7, 2022 11:38 AM

Full Author List

  • Kraft K; Yost KE; Murphy SE; Magg A; Long Y; Corces MR; Granja JM; Wittler L; Mundlos S; Cech TR

author count

  • 12

Other Profiles

International Standard Serial Number (ISSN)

  • 0027-8424

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Additional Document Info


  • 119


  • 22