research overview
- My research is on chromosome ends (telomeres) and their replication by telomerase.
- Contact Info
Cech, Thomas R Distinguished Professor, Nobel Laureate and Howard Hughes Medical Institute Investigator
Positions
- Distinguished Professor, Biochemistry
- Distinguished Professor, Molecular, Cellular & Developmental Biology (MCDB)
- Institute Director, Biofrontiers Institute
Research Areas
Research
keywords
- Interdisciplinary research and education
Publications
selected publications
-
chapter
- THE RNA WORLD THIRD EDITION The Nature of Modern RNA Suggests a Prebiotic RNA World Preface. Cold Spring Harbor Monograph Series. IX-X. 2006
- The RNP World. Cold Spring Harbor Monograph Series. 309-326. 2006
- Overturning the Dogma: Catalytic RNA 2001
- Building a Catalytic Active Site Using Only RNA 1999
- Structure and Mechanism of the Large Catalytic RNAs: Group I and Group II Introns and Ribonuclease P 1999
- RNA: Getting the Message 1995
- The Origin of Life and the Value of Life 1995
- Multiple Enzymatic Activities of an Intervening Sequence RNA from Tetrahymena 1987
- Viroids Contain Sequences Characteristic of Group I Introns 1987
- Ribosomal RNA Gene Expression in Tetrahymena: Transcription and RNA Splicing 1986
- Confrontational Dynamics Involved in RNA Self-Splicing 1986
- Mechanism of Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1986
- Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1983
-
conference proceeding
- TERT Promoter Mutations and Cancer. Federation proceedings. 2016
- TERT Promoter Mutations and Cancer. Federation proceedings. 2016
- MECHANISM AND STRUCTURE OF A CATALYTIC RNA MOLECULE. 91-110. 1993
-
journal article
-
Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Nucleic Acids Research.
8865-8875.
2018
-
A Lifelong Passion for All Things Ribonucleic.
Cell.
14-17.
2018
-
In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure.
1275-+.
2018
-
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.
Genes and Development.
794-805.
2018
-
Dynamics of human telomerase recruitment depend on template-telomere base pairing.
Cell regulation.
869-880.
2018
-
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
Cell Reports.
3700-3707.
2017
-
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.
Nature Structural Biology.
1028-+.
2017
-
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
eLife.
2017
-
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
Nature Communications.
2017
-
How do lncRNAs regulate transcription?.
Science Advances.
2017
-
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.
Molecular Cell.
1056-+.
2017
-
Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.
Genes and Development.
59-71.
2017
-
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Cell.
1188-+.
2016
-
RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.
Cell.
1267-1279.
2016
-
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Nature Structural Biology.
286-292.
2016
-
The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.
RNA.
2007-2022.
2015
-
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Genome Biology.
2015
-
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
Genes and Development.
2219-2224.
2015
-
Protein-RNA interaction restricts telomerase from running through the stop sign.
Nature Structural Biology.
835-836.
2015
-
Nucleic acid-binding specificity of human FUS protein.
Nucleic Acids Research.
7535-7543.
2015
-
Human telomerase: biogenesis, trafficking, recruitment, and activation.
Genes and Development.
1095-1105.
2015
-
RNA World research-still evolving.
RNA.
474-475.
2015
-
Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase.
Journal of Molecular Biology.
1291-1303.
2015
- Placental Expression of the lncRNA NEAT1 Increases in Preeclampsia. Journal of the Society for Gynecologic Investigation. 201A-201A. 2015
- Placental Expression of the lncRNA NEAT1, and Not MENb or TncRNA, Increases With Gestation. Journal of the Society for Gynecologic Investigation. 189A-189A. 2015
-
TERT promoter mutations and telomerase reactivation in urothelial cancer.
Science.
1006-1010.
2015
-
Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA.
Molecular Cell.
552-558.
2015
-
Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Journal of Cell Science.
331-341.
2015
-
Biochemical Properties and Biological Functions of FET Proteins.
Annual Review of Biochemistry.
355-379.
2015
-
Companies on campus.
Nature: New biology.
297-298.
2014
-
Academia and industry: Companies on campus..
Nature: New biology.
297-298.
2014
-
Identification of human TERT elements necessary for telomerase recruitment to telomeres.
eLife.
2014
-
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
Cell regulation.
2571-2578.
2014
-
Structure and Function of Steroid Receptor RNA Activator Protein, the Proposed Partner of SRA Noncoding RNA.
Journal of Molecular Biology.
1766-1785.
2014
-
The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones.
Cell.
77-94.
2014
-
Telomerase in Bladder Cancer: Back to a Better Future?.
European Urology.
370-371.
2014
-
Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.
Nucleic Acids Research.
8565-8577.
2014
-
NAR Breakthrough Article A dimeric state for PRC2.
Nucleic Acids Research.
9236-9248.
2014
-
Inhibition of Telomerase Recruitment and Cancer Cell Death.
Journal of Biological Chemistry.
33171-33180.
2013
-
Promiscuous RNA binding by Polycomb repressive complex 2.
Nature Structural Biology.
1250-U273.
2013
-
RNA Seeds Higher-Order Assembly of FUS Protein.
Cell Reports.
918-925.
2013
-
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Nucleic Acids Research.
8969-8978.
2013
-
3 ' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.
BMC Molecular Biology.
2013
-
RNA recognition by the DNA end-binding Ku heterodimer.
RNA.
841-851.
2013
-
Finding the end: recruitment of telomerase to telomeres.
Nature Reviews Molecular Cell Biology.
71-+.
2013
-
How a Chemist Looks at RNA.
Angewandte Chemie.
75-78.
2013
-
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.
Genes and Development.
2690-2695.
2012
-
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nature: New biology.
285-+.
2012
-
SnapShot: Telomeres and Telomerase.
Cell.
2012
-
The RNA Worlds in Context.
Cold Spring Harbor perspectives in biology.
2012
-
RNase P branches out from RNP to protein: organelle-triggered diversification?.
Genes and Development.
1005-1009.
2012
-
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model.
Cell.
922-932.
2012
- Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.. Cell. 922-32-922-32. 2012
-
DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
Nucleic Acids Research.
235-244.
2012
- DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.. 235-44-235-44. 2012
-
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Nature Structural Biology.
1371-U84.
2011
-
Multiple POT1-TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA.
Journal of Molecular Biology.
10-17.
2011
-
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Nature: New biology.
399-+.
2011
-
Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
RNA.
298-311.
2011
-
Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants.
Molecular and Cellular Biology.
4965-4976.
2010
-
Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Proceedings of the National Academy of Sciences.
4914-4918.
2010
-
Functional interaction between telomere protein TPP1 and telomerase.
Genes and Development.
613-622.
2010
-
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
EMBO Journal.
924-933.
2010
-
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proceedings of the National Academy of Sciences.
651-656.
2010
-
Crawling Out of the RNA World.
Cell.
599-602.
2009
-
A natural ribozyme with 3 ',5 ' RNA ligase activity.
Nature Chemical Biology.
97-99.
2009
-
Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Nucleic Acids Research.
354-367.
2009
-
Evolution of biological catalysis: ribozyme to RNP enzyme..
Cold Spring Harbor Symposia on Quantitative Biology.
11-16.
2009
-
Toward predicting self-splicing and protein-facilitated splicing of group I introns.
RNA.
2013-2029.
2008
-
Mutation in TERT separates processivity from anchor-site function.
Nature Structural Biology.
871-872.
2008
-
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Molecular and Cellular Biology.
4152-4161.
2008
-
Triple-helix structure in telomerase RNA contributes to catalysis.
Nature Structural Biology.
634-640.
2008
-
On the occasion of the 25(th) anniversary of the discovery of catalytic RNA.
Biological Chemistry.
661-662.
2007
-
Local RNA structural changes induced by crystallization are revealed by SHAPE.
RNA.
536-548.
2007
-
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature: New biology.
506-510.
2007
-
Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency.
RNA.
1721-1737.
2006
- Crystal structure of an essential telomerase-specific domain of TERT. Federation proceedings. A984-A984. 2006
-
Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.
RNA.
387-395.
2006
-
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Nature Structural Biology.
218-225.
2006
-
Atomic level architecture of group I introns revealed.
Trends in Biochemical Sciences.
41-51.
2006
-
RNA as a flexible scaffold for proteins: Yeast telomerase and beyond.
Cold Spring Harbor Symposia on Quantitative Biology.
217-224.
2006
-
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Nature Structural Biology.
1072-1077.
2005
-
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
Journal of Biological Chemistry.
32069-32080.
2005
-
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Proceedings of the National Academy of Sciences.
10864-10869.
2005
-
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Protein Science.
2051-2058.
2005
-
Switching human telomerase on and off with hPOT1 protein in vitro.
Journal of Biological Chemistry.
20449-20456.
2005
-
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Journal of Biological Chemistry.
5249-5257.
2005
- Fostering innovation and discovery in biomedical research.. 1390-3-1390-3. 2005
- Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biology. 2005
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Nature Structural Biology.
1223-1229.
2004
-
Structure of the Tetrahymena ribozyme: Base triple sandwich and metal ion at the active site.
Molecular Cell.
351-362.
2004
-
Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Bioscience Reports.
362-385.
2004
-
Yeast telomerase RNA: A flexible scaffold for protein subunits.
Proceedings of the National Academy of Sciences.
10024-10029.
2004
-
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
RNA.
1108-1118.
2004
-
RNA finds a simpler way.
Nature: New biology.
263-264.
2004
-
Beginning to understand the end of the chromosome.
Cell.
273-279.
2004
- Nurturing interdisciplinary research.. 1166-9-1166-9. 2004
-
Tetrahymena telomerase is active as a monomer.
Cell regulation.
4794-4804.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Nature: New biology.
198-203.
2003
-
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA.
1323-1332.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA..
Nature: New biology.
198-203.
2003
-
Sequence-specific and 3 '-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit.
Biochemistry.
9269-9277.
2003
-
Human POT1 facilitates telomere elongation by telomerase.
Current Biology.
942-946.
2003
-
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Biochemistry.
5736-5747.
2003
-
Yeast telomerase is specialized for C/A-rich RNA templates.
Nucleic Acids Research.
1646-1655.
2003
-
Rebalancing teaching and research.
Science.
165-165.
2003
-
N-terminal domain of yeast telomerase reverse transcriptase: Recruitment of Est3p to the telomerase complex.
Cell regulation.
1-13.
2003
- Sharing publication-related data and materials: responsibilities of authorship in the life sciences.. 19-24-19-24. 2003
-
Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.
Biochemistry.
14560-14568.
2002
-
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes and Development.
2800-2812.
2002
-
Evolution of Tetrahymena ribozyme mutants with increased structural stability.
Nature Structural Biology.
855-861.
2002
-
Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing.
Molecular and Cellular Biology.
8079-8087.
2002
-
Ribozymes, the first 20 years.
Biochemical Society Transactions.
1162-1166.
2002
-
The chemical repertoire of natural ribozymes.
Nature: New biology.
222-228.
2002
-
In vivo selection of better self-splicing introns in Escherichia coli: The role of the P1 extension helix of the Tetrahymena intron.
RNA.
647-658.
2002
-
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction..
Molecular and Cellular Biology.
2366-2374.
2002
-
Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: Evidence for product-assisted translocation.
Biochemistry.
151-161.
2002
-
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
Biochemistry.
7005-7016.
2001
-
Pot1, the putative telomere end-binding protein in fission yeast and humans.
Science.
1171-1175.
2001
-
Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry..
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].
Unit-5.1.
2001
-
Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA-solvent interactions.
Structure.
221-231.
2001
- Two RNA machines: Ribozyme and telomerase. Federation proceedings. A57-A57. 2001
-
An early transition state for folding of the P4-P6 RNA domain.
RNA.
161-166.
2001
- Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry.. Unit 5.1-Unit 5.1. 2001
- Science and business. Conflicts of interest–moving beyond disclosure.. Science. 989-989. 2001
-
Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
EMBO Journal.
6230-6239.
2000
-
Multiple folding pathways for the P4-P6 RNA domain.
Biochemistry.
12465-12475.
2000
-
Protection of telomeres by the Ku protein in fission yeast.
Cell regulation.
3265-3275.
2000
-
A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
Journal of Biological Chemistry.
24199-24207.
2000
-
Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.
Molecular Cell.
493-499.
2000
-
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences.
6367-6372.
2000
-
Life at the end of the chromosome: Telomeres and telomerase.
Angewandte Chemie.
34-43.
2000
- Structural biology. The ribosome is a ribozyme.. Science. 878-9-878-9. 2000
-
Quantifying the energetic interplay of RNA tertiary and secondary structure interactions.
RNA.
1665-1674.
1999
- Science at liberal arts colleges: A better education?. Daedalus. 195-216. 1999
-
Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.
EMBO Journal.
6491-6500.
1999
-
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
Genes and Development.
2863-2874.
1999
-
RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Biochemistry.
14224-14237.
1999
- Hot papers - Telomerase - Telomerase catalytic subunit homologs from fission yeast and human by T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, T.E. Cech - Comments. Scientist -Philadelphia-. 14-14. 1999
- Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature: New biology. 177-180. 1999
-
In vitro selection of RNAs with increased tertiary structure stability.
RNA.
1119-1129.
1999
-
Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Biochemistry.
8691-8702.
1999
-
Telomerase and the maintenance of chromosome ends.
Current Opinion in Cell Biology.
318-324.
1999
-
In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity.
RNA.
1481-1492.
1998
-
Two modes of survival of fission yeast without telomerase.
Science.
493-496.
1998
-
A preorganized active site in the crystal structure of the Tetrahymena ribozyme.
Science.
259-264.
1998
-
A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps.
RNA.
1179-1185.
1998
-
Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features.
Cell Chemistry Biology.
539-553.
1998
-
Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis.
Biochemistry.
11162-11170.
1998
-
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Proceedings of the National Academy of Sciences.
8479-8484.
1998
-
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.
Genes and Development.
1504-1514.
1998
-
Binding of the protein kinase PKR to RNAs with secondary structure defects: Role of the tandem A-G mismatch and noncontiguous helixes.
Biochemistry.
6303-6316.
1998
-
Euplotes telomerase: Evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation.
Biochemistry.
5162-5172.
1998
-
Telomerase and chromosome end maintenance.
Current Opinion in Genetics and Development.
226-232.
1998
-
Reversing time: Origin of telomerase.
Cell.
587-590.
1998
- Are telomeres correlative or causative in cellular senescence? General discussion. Ciba Foundation symposium. 145-147. 1998
- Human ageing and telomeres - Discussion. Ciba Foundation symposium. 139-144. 1998
- Mouse models for the study of telomerase - Discussion. Ciba Foundation symposium. 170-176. 1998
- Repair and processing events at DNA ends - Discussion. Ciba Foundation symposium. 205-208. 1998
- Telomerase and the chromosome end replication problem. Ciba Foundation symposium. 20-28. 1998
- Telomerase assays in the diagnosis and prognosis of cancer - Discussion. Ciba Foundation symposium. 155-159. 1998
- Telomeres and telomerase in other organisms. Ciba Foundation symposium. 223-226. 1998
- Telomeres in the haemopoietic system - Discussion. Ciba Foundation symposium. 219-222. 1998
-
Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis.
Biochemistry.
16345-16354.
1997
-
Peptide bond formation by in vitro selected ribozymes.
Nature: New biology.
96-100.
1997
- Polyadenylation of telomerase RNA in budding yeast. RNA. 1337-1351. 1997
- Telomerase is a true reverse transcriptase. A review. Biokhimiia (Moscow, Russia). 1202-1205. 1997
-
Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity.
Proceedings of the National Academy of Sciences.
11190-11195.
1997
-
dGTP-dependent processivity and possible template switching of Euplotes telomerase.
Nucleic Acids Research.
3698-3704.
1997
- Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1037-1051. 1997
-
A second catalytic metal ion in a group I ribozyme.
Nature: New biology.
805-808.
1997
-
Telomerase catalytic subunit homologs from fission yeast and human.
Science.
955-959.
1997
- An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 838-849. 1997
-
Crystals by design: A strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron.
Journal of Molecular Biology.
711-723.
1997
-
Dynamics of thermal motions within a large catalytic RNA investigated by cross-linking with thiol-disulfide interchange.
Journal of the American Chemical Society.
6259-6268.
1997
-
Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction.
Biochemistry.
8293-8303.
1997
-
Reverse transcriptase motifs in the catalytic subunit of telomerase.
Science.
561-567.
1997
-
Regulation of telomere length and function by a Myb-domain protein in fission yeast.
Nature: New biology.
744-747.
1997
-
Joining the two domains of a group I ribozyme to form the catalytic core.
Science.
847-849.
1997
-
The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers.
Molecular and Cellular Biology.
296-308.
1997
- X-ray crystallography of large RNAs: Heavy-atom derivatives by RNA engineering. RNA. 1295-1305. 1996
-
The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena.
Genes and Development.
2870-2880.
1996
-
Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage.
Journal of the American Chemical Society.
10341-10350.
1996
-
Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes.
Nucleic Acids Research.
3722-3727.
1996
-
Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3' overhang.
Proceedings of the National Academy of Sciences.
10712-10717.
1996
-
Crystal structure of a group I ribozyme domain: Principles of RNA packing.
Science.
1678-1685.
1996
- RNA tertiary structure mediation by adenosine platforms. Science. 1696-1699. 1996
-
Mutations in the Tetrahymena ribozyme internal guide sequence: Effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.
Biochemistry.
11493-11502.
1996
-
Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.
Biochemistry.
9983-9994.
1996
- Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. RNA. 718-732. 1996
-
Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila.
EMBO Journal.
3286-3295.
1996
- Selecting apt RNAs for NMR. RNA. 625-627. 1996
-
Conformational switches involved in orchestrating the successive steps of group I RNA splicing.
Biochemistry.
3754-3763.
1996
-
Method for determining RNA 3' ends and application to human telomerase RNA.
Nucleic Acids Research.
532-533.
1996
-
Exocyclic amine of the conserved G center dot U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization.
Biochemistry.
1201-1211.
1996
-
Assembly of a ribonucleoprotein catalyst by tertiary structure capture.
Science.
345-348.
1996
- Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(IIe) of the purple bacterium Azoarcus. RNA. 74-83. 1996
-
RELATIVE ORIENTATION OF RNA HELICES IN A GROUP-I RIBOZYME DETERMINED BY HELIX EXTENSION ELECTRON-MICROSCOPY.
EMBO Journal.
4849-4859.
1995
-
TELOMERASE AND DNA END REPLICATION - NO LONGER A LAGGING-STRAND PROBLEM.
Science.
1533-1534.
1995
- IDENTIFICATION OF RIBOZYMES WITHIN A RIBOZYME LIBRARY THAT EFFICIENTLY CLEAVE A LONG SUBSTRATE RNA. RNA. 598-609. 1995
-
PROTEIN FACILITATION OF GROUP-I INTRON SPLICING BY ASSEMBLY OF THE CATALYTIC CORE AND THE 5'-SPLICE-SITE DOMAIN.
Cell.
221-230.
1995
-
TELOMERASE RNA LOCALIZED IN THE REPLICATION BAND AND SPHERICAL SUBNUCLEAR ORGANELLES IN HYPOTRICHOUS CILIATES.
Journal of Cell Biology.
243-253.
1995
-
EFFICIENT PROTEIN-FACILITATED SPLICING OF THE YEAST MITOCHONDRIAL BI5 INTRON.
Biochemistry.
7728-7738.
1995
-
PHOSPHORYLATION OF THE OXYTRICHA TELOMERE PROTEIN - POSSIBLE CELL-CYCLE REGULATION.
Nucleic Acids Research.
1887-1893.
1995
- AN IMPORTANT RNA TERTIARY INTERACTION OF GROUP-I AND GROUP-II INTRONS IS IMPLICATED IN GRAM-POSITIVE RNASE-P RNAS. RNA. 349-350. 1995
- ANALYSIS OF THE STRUCTURE OF TETRAHYMENA NUCLEAR RNAS IN-VIVO - TELOMERASE RNA, THE SELF-SPLICING RIBOSOMAL-RNA INTRON, AND U2 SNRNA. RNA. 363-374. 1995
-
A POSITIVE ENTROPY CHANGE FOR GUANOSINE BINDING AND FOR THE CHEMICAL STEP IN THE TETRAHYMENA RIBOZYME REACTION.
Biochemistry.
4056-4067.
1995
- THROUGH THE GLASS LIGHTLY. Science. 1609-1618. 1995
-
SELECTION OF AN RNA MOLECULE THAT MIMICS A MAJOR AUTOANTIGENIC EPITOPE OF HUMAN INSULIN-RECEPTOR.
Proceedings of the National Academy of Sciences.
2355-2359.
1995
- SELF-ASSEMBLY OF A GROUP-I INTRON ACTIVE-SITE FROM ITS COMPONENT TERTIARY STRUCTURAL DOMAINS. RNA. 36-45. 1995
-
MINOR-GROOVE RECOGNITION OF THE CONSERVED G-CENTER-DOT-U PAIR AT THE TETRAHYMENA RIBOZYME REACTION SITE.
Science.
675-679.
1995
- A TALE OF 2 RIBOZYMES AND 2 TAILS ON A RIBOZYME. Journal of Cellular Biochemistry. 200-200. 1995
- STRUCTURE AND MECHANISM OF A GROUP-I RIBOZYME AND APPLICATIONS IN BIOTECHNOLOGY. Protein Engineering -Oxford-. 16-16. 1995
- Through the Glass Lightly.. Science. 1611-1611. 1995
-
CATALYSIS OF RNA CLEAVAGE BY A RIBOZYME DERIVED FROM THE GROUP-I INTRON OF ANABAENA PRE-TRNA(LEU).
Biochemistry.
14935-14947.
1994
-
REPLACEMENT OF THE CONSERVED G-CENTER-DOT-U WITH A G-C PAIR AT THE CLEAVAGE SITE OF THE TETRAHYMENA RIBOZYME DECREASES BINDING, REACTIVITY, AND FIDELITY.
Biochemistry.
13856-13863.
1994
-
THE 2,6-DIAMINOPURINE RIBOSIDE-CENTER-DOT-5-METHYLISOCYTIDINE WOBBLE BASE-PAIR - AN ISOENERGETIC SUBSTITUTION FOR THE STUDY OF G-CENTER-DOT-U PAIRS IN RNA.
Biochemistry.
13824-13835.
1994
-
RIBOZYMES - HAMMERHEAD NAILED DOWN.
Nature: New biology.
39-40.
1994
-
CHROMOSOME END GAMES.
Science.
387-388.
1994
-
RIBOZYME-MEDIATED REPAIR OF DEFECTIVE MESSENGER-RNA BY TARGETED TRANSSPLICING.
Nature: New biology.
619-622.
1994
-
COAXIALLY STACKED RNA HELICES IN THE CATALYTIC CENTER OF THE TETRAHYMENA RIBOZYME.
Science.
1709-1712.
1994
-
TELOMERASE RNAS OF DIFFERENT CILIATES HAVE A COMMON SECONDARY STRUCTURE AND A PERMUTED TEMPLATE.
Genes and Development.
1984-1998.
1994
-
2 MAJOR TERTIARY FOLDING TRANSITIONS OF THE TETRAHYMENA CATALYTIC RNA.
EMBO Journal.
2669-2676.
1994
- Two major tertiary folding transitions of the Tetrahymena catalytic RNA.. EMBO Journal. 2669-2676. 1994
-
METAL-ION DEPENDENCE OF ACTIVE-SITE STRUCTURE OF THE TETRAHYMENA RIBOZYME REVEALED BY SITE-SPECIFIC PHOTO-CROSS-LINKING.
Journal of the American Chemical Society.
4178-4182.
1994
-
A TERTIARY INTERACTION IN THE TETRAHYMENA INTRON CONTRIBUTES TO SELECTION OF THE 5' SPLICE-SITE.
Genes and Development.
1198-1211.
1994
-
REPRESENTATION OF THE SECONDARY AND TERTIARY STRUCTURE OF GROUP-I INTRONS.
Nature Structural Biology.
273-280.
1994
-
TELOMERIC PROTEIN-DNA POINT CONTACTS IDENTIFIED BY PHOTO-CROSS-LINKING USING 5-BROMODEOXYURIDINE.
Biochemistry.
3364-3373.
1994
- OXYTRICHA TELOMERE-BINDING PROTEIN - DNA-DEPENDENT ALPHA-BETA SUBUNIT INTERACTION AND SEPARABLE DNA-BINDING AND DIMERIZATION DOMAINS OF THE ALPHA-SUBUNIT. Journal of Cellular Biochemistry. 132-132. 1994
- OXYTRICHA TELOMERE-BINDING PROTEIN PROMOTES G-QUARTET FORMATION BY TELOMERIC DNA. Journal of Cellular Biochemistry. 124-124. 1994
-
GAAA TETRALOOP AND CONSERVED BULGE STABILIZE TERTIARY STRUCTURE OF A GROUP-I INTRON DOMAIN.
Journal of Molecular Biology.
49-63.
1994
-
VISUALIZATION OF A TERTIARY STRUCTURAL DOMAIN OF THE TETRAHYMENA GROUP-I INTRON BY ELECTRON-MICROSCOPY.
Journal of Molecular Biology.
64-71.
1994
-
TRANSLOCATION OF AN RNA DUPLEX ON A RIBOZYME.
Nature Structural Biology.
13-17.
1994
-
THE EFFICIENCY AND VERSATILITY OF CATALYTIC RNA - IMPLICATIONS FOR AN RNA WORLD.
Gene.
33-36.
1993
-
TERTIARY INTERACTIONS WITH THE INTERNAL GUIDE SEQUENCE MEDIATE DOCKING OF THE P1 HELIX INTO THE CATALYTIC CORE OF THE TETRAHYMENA RIBOZYME.
Biochemistry.
13593-13604.
1993
-
TETHERING RIBOZYMES TO A RETROVIRAL PACKAGING SIGNAL FOR DESTRUCTION OF VIRAL-RNA.
Science.
1566-1569.
1993
-
PHOTO-CROSS-LINKING OF 5-IODOURACIL SUBSTITUTED RNA AND DNA TO PROTEINS.
Science.
1255-1257.
1993
-
CHARACTERIZATION OF A G-QUARTET FORMATION REACTION PROMOTED BY THE BETA-SUBUNIT OF THE OXYTRICHA TELOMERE-BINDING PROTEIN.
Biochemistry.
11646-11657.
1993
-
RNA - FISHING FOR FRESH CATALYSTS.
Nature: New biology.
204-205.
1993
-
GUANOSINE BINDING TO THE TETRAHYMENA RIBOZYME - THERMODYNAMIC COUPLING WITH OLIGONUCLEOTIDE BINDING.
Proceedings of the National Academy of Sciences.
8362-8366.
1993
-
THE BETA-SUBUNIT OF OXYTRICHA TELOMERE-BINDING PROTEIN PROMOTES G-QUARTET FORMATION BY TELOMERIC DNA.
Cell.
875-885.
1993
-
CONTRIBUTIONS OF 2'-HYDROXYL GROUPS OF THE RNA SUBSTRATE TO BINDING AND CATALYSIS BY THE TETRAHYMENA RIBOZYME - AN ENERGETIC PICTURE OF AN ACTIVE-SITE COMPOSED OF RNA.
Biochemistry.
8299-8311.
1993
-
THE IMPORTANCE OF BEING RIBOSE AT THE CLEAVAGE SITE IN THE TETRAHYMENA RIBOZYME REACTION.
Biochemistry.
8312-8321.
1993
-
SELF-SPLICING OF THE GROUP-I INTRON FROM ANABAENA PRE-TRANSFER-RNA - REQUIREMENT FOR BASE-PAIRING OF THE EXONS IN THE ANTICODON STEM.
Biochemistry.
7946-7953.
1993
-
NUCLEAR PROTEINS THAT BIND THE PREMESSENGER RNA 3' SPLICE-SITE SEQUENCE R(UUAG/G) AND THE HUMAN TELOMERIC DNA-SEQUENCE D(TTAGGG)N.
Molecular and Cellular Biology.
4301-4310.
1993
-
OXYTRICHA TELOMERE-BINDING PROTEIN - DNA-DEPENDENT DIMERIZATION OF THE ALPHA-SUBUNIT AND BETA-SUBUNIT.
Proceedings of the National Academy of Sciences.
6056-6060.
1993
-
AN INDEPENDENTLY FOLDING DOMAIN OF RNA TERTIARY STRUCTURE WITHIN THE TETRAHYMENA RIBOZYME.
Biochemistry.
5291-5300.
1993
-
CATALYTIC RNA - STRUCTURE AND MECHANISM.
Biochemical Society Transactions.
229-234.
1993
-
OXYTRICHA TELOMERE-BINDING PROTEIN - SEPARABLE DNA-BINDING AND DIMERIZATION DOMAINS OF THE ALPHA-SUBUNIT.
Genes and Development.
870-882.
1993
-
MOVEMENT OF THE GUIDE SEQUENCE DURING RNA CATALYSIS BY A GROUP-I RIBOZYME.
Science.
504-508.
1993
- RNA CATALYSIS - WHAT, HOW, WHY AND WHERE. Federation proceedings. A1057-A1057. 1993
- HIGH-YIELD PHOTO-CROSS-LINKING BETWEEN 5-HALOURACIL SUBSTITUTED NUCLEIC-ACIDS AND ASSOCIATED PROTEINS. ACS National Meeting Book of Abstracts. 11-ORGN. 1993
- METAL-ION CATALYSIS BY THE TETRAHYMENA-RIBOZYME. ACS National Meeting Book of Abstracts. 211-INOR. 1993
- MECHANISM OF NUCLEASE ACTIVITY OF A GROUP-I RIBOZYME. Journal of Cellular Biochemistry. 159-159. 1993
-
METAL-ION CATALYSIS IN THE TETRAHYMENA RIBOZYME REACTION.
Nature: New biology.
85-88.
1993
-
MUTATIONS AT THE GUANOSINE-BINDING SITE OF THE TETRAHYMENA RIBOZYME ALSO AFFECT SITE-SPECIFIC HYDROLYSIS.
Nucleic Acids Research.
6613-6619.
1992
- RNA CATALYSIS BY A GROUP-I RIBOZYME - DEVELOPING A MODEL FOR TRANSITION-STATE STABILIZATION. Journal of Biological Chemistry. 17479-17482. 1992
- 3-DIMENSIONAL STRUCTURE OF THE TETRAHYMENA RIBOZYME REVEALED BY PHOTOCROSSLINK AND AFFINITY CLEAVAGE. ACS National Meeting Book of Abstracts. 167-ORGN. 1992
-
RNA SUBSTRATE BINDING-SITE IN THE CATALYTIC CORE OF THE TETRAHYMENA RIBOZYME.
Nature: New biology.
123-131.
1992
-
AMINOACYL ESTERASE-ACTIVITY OF THE TETRAHYMENA RIBOZYME.
Science.
1420-1424.
1992
-
TERTIARY STRUCTURE AROUND THE GUANOSINE-BINDING SITE OF THE TETRAHYMENA RIBOZYME.
Science.
526-529.
1992
- PHOSPHATE RECOGNITION BY A RIBOZYME. Federation proceedings. A412-A412. 1992
- The intervening sequence RNA of Tetrahymena is an enzyme. 1986.. Biotechnology (Reading, Mass.). 57-62. 1992
-
FOLDING OF GROUP-I INTRONS FROM BACTERIOPHAGE-T4 INVOLVES INTERNALIZATION OF THE CATALYTIC CORE.
Proceedings of the National Academy of Sciences.
11105-11109.
1991
-
MUTATIONS IN A NONCONSERVED SEQUENCE OF THE TETRAHYMENA RIBOZYME INCREASE ACTIVITY AND SPECIFICITY.
Cell.
1007-1019.
1991
-
CLONING AND EXPRESSION OF GENES FOR THE OXYTRICHA TELOMERE-BINDING PROTEIN - SPECIFIC SUBUNIT INTERACTIONS IN THE TELOMERIC COMPLEX.
Cell.
807-814.
1991
-
MOLECULAR-CLONING OF TELOMERE-BINDING PROTEIN GENES FROM STYLONYCHIA-MYTILIS.
Nucleic Acids Research.
5515-5518.
1991
-
BINDING OF THE CBP2 PROTEIN TO A YEAST MITOCHONDRIAL GROUP-I INTRON REQUIRES THE CATALYTIC CORE OF THE RNA.
Genes and Development.
1870-1880.
1991
-
A SELF-SPLICING GROUP-I INTRON IN THE NUCLEAR PRE-RIBOSOMAL-RNA OF THE GREEN-ALGA, ANKISTRODESMUS-STIPITATUS.
Nucleic Acids Research.
4429-4436.
1991
-
A HAMMERHEAD RIBOZYME ALLOWS SYNTHESIS OF A NEW FORM OF THE TETRAHYMENA RIBOZYME HOMOGENEOUS IN LENGTH WITH A 3' END BLOCKED FOR TRANSESTERIFICATION.
Nucleic Acids Research.
3875-3880.
1991
-
RIBOZYME-CATALYZED AND NONENZYMATIC REACTIONS OF PHOSPHATE DIESTERS - RATE EFFECTS UPON SUBSTITUTION OF SULFUR FOR A NONBRIDGING PHOSPHORYL OXYGEN ATOM.
Biochemistry.
4844-4854.
1991
-
INHIBITION OF TELOMERASE BY G-QUARTET DNA STRUCTURES.
Nature: New biology.
718-720.
1991
-
RIBOZYME RECOGNITION OF RNA BY TERTIARY INTERACTIONS WITH SPECIFIC RIBOSE 2'-OH GROUPS.
Nature: New biology.
628-631.
1991
-
ALTERNATIVE SECONDARY STRUCTURES IN THE 5' EXON AFFECT BOTH FORWARD AND REVERSE SELF-SPLICING OF THE TETRAHYMENA INTERVENING SEQUENCE RNA.
Biochemistry.
2042-2050.
1991
-
RNA EDITING - WORLDS SMALLEST INTRONS.
Cell.
667-669.
1991
-
VISUALIZING THE HIGHER-ORDER FOLDING OF A CATALYTIC RNA MOLECULE.
Science.
401-407.
1991
-
CATALYSIS OF RNA CLEAVAGE BY THE TETRAHYMENA-THERMOPHILA RIBOZYME .1. KINETIC DESCRIPTION OF THE REACTION OF AN RNA SUBSTRATE COMPLEMENTARY TO THE ACTIVE-SITE.
Biochemistry.
10159-10171.
1990
-
CATALYSIS OF RNA CLEAVAGE BY THE TETRAHYMENA-THERMOPHILA RIBOZYME .2. KINETIC DESCRIPTION OF THE REACTION OF AN RNA SUBSTRATE THAT FORMS A MISMATCH AT THE ACTIVE-SITE.
Biochemistry.
10172-10180.
1990
-
DIRECT MEASUREMENT OF OLIGONUCLEOTIDE SUBSTRATE BINDING TO WILD-TYPE AND MUTANT RIBOZYMES FROM TETRAHYMENA.
Proceedings of the National Academy of Sciences.
8187-8191.
1990
-
EFFECT OF MONOVALENT CATION-INDUCED TELOMERIC DNA-STRUCTURE ON THE BINDING OF OXYTRICHA TELOMERIC PROTEIN.
Nucleic Acids Research.
4543-4551.
1990
-
SELF-SPLICING AND ENZYMATIC-ACTIVITY OF AN INTERVENING SEQUENCE RNA FROM TETRAHYMENA.
Angewandte Chemie.
759-768.
1990
-
AN ULTRAVIOLET-INDUCIBLE ADENOSINE ADENOSINE CROSS-LINK REFLECTS THE CATALYTIC STRUCTURE OF THE TETRAHYMENA RIBOZYME.
Biochemistry.
5605-5613.
1990
-
SELF-SPLICING AND ENZYMATIC-ACTIVITY OF AN INTERVENING SEQUENCE RNA FROM TETRAHYMENA.
Bioscience Reports.
239-261.
1990
-
SELF-SPLICING AND ENZYMATIC-ACTIVITY OF AN INTERVENING SEQUENCE RNA FROM TETRAHYMENA.
Bioscience Reports.
239-261.
1990
-
DNA CLEAVAGE CATALYZED BY THE RIBOZYME FROM TETRAHYMENA.
Nature: New biology.
405-409.
1990
-
IRON(II)-ETHYLENEDIAMINETETRAACETIC ACID-CATALYZED CLEAVAGE OF RNA AND DNA OLIGONUCLEOTIDES - SIMILAR REACTIVITY TOWARD SINGLE-STRANDED AND DOUBLE-STRANDED FORMS.
Biochemistry.
1355-1361.
1990
-
2 VERSIONS OF THE GENE ENCODING THE 41-KILODALTON SUBUNIT OF THE TELOMERE BINDING-PROTEIN OF OXYTRICHA-NOVA.
Proceedings of the National Academy of Sciences.
1481-1485.
1990
-
2 VERSIONS OF THE GENE ENCODING THE 41-KILODALTON SUBUNIT OF THE TELOMERE BINDING-PROTEIN OF OXYTRICHA-NOVA.
Proceedings of the National Academy of Sciences.
1481-1485.
1990
- SELF-SPLICING AND ENZYMATIC CLEAVAGE OF RNA BY A GROUP-I INTERVENING SEQUENCE. Methods in Enzymology. 558-568. 1990
-
SELF-SPLICING OF GROUP-I INTRONS.
Annual Review of Biochemistry.
543-568.
1990
-
Self-splicing of group I introns..
Annual Review of Biochemistry.
543-568.
1990
-
ALTERATION OF SUBSTRATE-SPECIFICITY FOR THE ENDORIBONUCLEOLYTIC CLEAVAGE OF RNA BY THE TETRAHYMENA RIBOZYME.
Proceedings of the National Academy of Sciences.
9218-9222.
1989
-
MONO-VALENT CATION INDUCED STRUCTURE OF TELOMERIC DNA - THE G-QUARTET MODEL.
Cell.
871-880.
1989
-
ASSEMBLY AND SELF-ASSOCIATION OF OXYTRICHA TELOMERIC NUCLEOPROTEIN COMPLEXES.
Cell.
719-728.
1989
-
A CONSERVED BASE PAIR WITHIN HELIX-P4 OF THE TETRAHYMENA RIBOZYME HELPS TO FORM THE TERTIARY STRUCTURE REQUIRED FOR SELF-SPLICING.
EMBO Journal.
3391-3399.
1989
-
A TETRAHYMENA INTRON NUCLEOTIDE CONNECTED TO THE GTP ARGININE SITE.
Nucleic Acids Research.
6969-6981.
1989
-
THE CONSERVED U.G PAIR IN THE 5' SPLICE SITE DUPLEX OF A GROUP-I INTRON IS REQUIRED IN THE 1ST BUT NOT THE 2ND STEP OF SELF-SPLICING.
Molecular and Cellular Biology.
3657-3666.
1989
-
METAL-ION REQUIREMENTS FOR SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME.
Biochemistry.
6888-6894.
1989
-
DEFINING THE INSIDE AND OUTSIDE OF A CATALYTIC RNA MOLECULE.
Science.
276-282.
1989
-
RNA CHEMISTRY - RIBOZYME SELF-REPLICATION.
Nature: New biology.
507-508.
1989
-
OXYTRICHA TELOMERIC NUCLEOPROTEIN COMPLEXES RECONSTITUTED WITH SYNTHETIC DNA.
Nucleic Acids Research.
4235-4253.
1989
-
STEREOCHEMISTRY OF RNA CLEAVAGE BY THE TETRAHYMENA RIBOZYME AND EVIDENCE THAT THE CHEMICAL STEP IS NOT RATE-LIMITING.
Science.
679-683.
1989
-
REVERSE SELF-SPLICING OF THE TETRAHYMENA GROUP-I INTRON - IMPLICATION FOR THE DIRECTIONALITY OF SPLICING AND FOR INTRON TRANSPOSITION.
Cell.
335-345.
1989
-
PROPERTIES OF THE TELOMERIC DNA-BINDING PROTEIN FROM OXYTRICHA-NOVA.
Biochemistry.
769-774.
1989
- RNA AS AN ENZYME. Biochemistry International. 7-14. 1989
-
SPECIFICITY FOR 3',5'-LINKED SUBSTRATES IN RNA-CATALYZED RNA POLYMERIZATION.
Journal of Molecular Evolution.
480-485.
1989
-
CONSERVED SEQUENCES AND STRUCTURES OF GROUP-I INTRONS - BUILDING AN ACTIVE-SITE FOR RNA CATALYSIS - A REVIEW.
Gene.
259-271.
1988
-
SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME - ENHANCED CLEAVAGE OF CERTAIN OLIGONUCLEOTIDE SUBSTRATES THAT FORM MISMATCHED RIBOZYME SUBSTRATE COMPLEXES.
Biochemistry.
8924-8931.
1988
- RIBOZYMES AND THEIR MEDICAL IMPLICATIONS. Journal of the American Medical Association. 3030-3034. 1988
-
DETERMINANTS OF THE 3' SPLICE SITE FOR SELF-SPLICING OF THE TETRAHYMENA PRE-RRNA.
Genes and Development.
1439-1447.
1988
-
TELOMERIC REPEATS OF TETRAHYMENA-MALACCENSIS MITOCHONDRIAL-DNA - A MULTIMODAL DISTRIBUTION THAT FLUCTUATES ERRATICALLY DURING GROWTH.
Molecular and Cellular Biology.
4450-4458.
1988
-
DELETION OF NONCONSERVED HELICES NEAR THE 3' END OF THE RIBOSOMAL-RNA INTRON OF TETRAHYMENA-THERMOPHILA ALTERS SELF-SPLICING BUT NOT CORE CATALYTIC ACTIVITY.
Genes and Development.
652-663.
1988
-
DNA BIOCHEMISTRY - G-STRINGS AT CHROMOSOME ENDS.
Nature: New biology.
777-778.
1988
-
RNA AS AN RNA-POLYMERASE - NET ELONGATION OF AN RNA PRIMER CATALYZED BY THE TETRAHYMENA RIBOZYME.
Science.
1412-1416.
1988
-
MITOCHONDRIAL TELOMERES - SURPRISING DIVERSITY OF REPEATED TELOMERIC DNA-SEQUENCES AMONG 6 SPECIES OF TETRAHYMENA.
Cell.
367-374.
1988
-
PHYLOGENETIC-RELATIONSHIPS AND ALTERED GENOME STRUCTURES AMONG TETRAHYMENA MITOCHONDRIAL DNAS.
Nucleic Acids Research.
327-346.
1988
- BIOLOGIC CATALYSIS BY RNA. Harvey Lectures. 123-144. 1988
-
3-DIMENSIONAL MODEL OF THE ACTIVE-SITE OF THE SELF-SPLICING RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA.
Proceedings of the National Academy of Sciences.
8788-8792.
1987
-
SELF-SPLICING RNA AND AN RNA ENZYME IN TETRAHYMENA.
The Journal of protozoology.
416-417.
1987
-
TELOMERIC DNA PROTEIN INTERACTIONS OF OXYTRICHA MACRONUCLEAR DNA.
Genes and Development.
783-793.
1987
-
STRUCTURAL CONVENTIONS FOR GROUP-I INTRONS.
Nucleic Acids Research.
7217-7221.
1987
-
SELECTION OF CIRCULARIZATION SITES IN A GROUP-1 IVS RNA REQUIRES MULTIPLE ALIGNMENTS OF AN INTERNAL TEMPLATE-LIKE SEQUENCE.
Cell.
951-961.
1987
-
5' EXON REQUIREMENT FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA AND IDENTIFICATION OF A CRYPTIC 5' SPLICE SITE IN THE 3' EXON.
Journal of Molecular Biology.
49-60.
1987
-
THE CHEMISTRY OF SELF-SPLICING RNA AND RNA ENZYMES.
Science.
1532-1539.
1987
-
GUANOSINE BINDING REQUIRED FOR CYCLIZATION OF THE SELF-SPLICING INTERVENING SEQUENCE RIBONUCLEIC-ACID FROM TETRAHYMENA-THERMOPHILA.
Biochemistry.
3330-3340.
1987
- RNA AS AN ENZYME. Federation proceedings. 2020-2020. 1987
-
STRUCTURES INVOLVED IN TETRAHYMENA RIBOSOMAL-RNA SELF-SPLICING AND RNA ENZYME-ACTIVITY.
Cold Spring Harbor Symposia on Quantitative Biology.
147-157.
1987
-
THE TETRAHYMENA RIBOZYME ACTS LIKE AN RNA RESTRICTION ENDONUCLEASE.
Nature: New biology.
429-433.
1986
-
RNA AS AN ENZYME.
Scientific American.
64-&.
1986
-
ONE BINDING-SITE DETERMINES SEQUENCE SPECIFICITY OF TETRAHYMENA PRE-RIBOSOMAL-RNA SELF-SPLICING, TRANSSPLICING, AND RNA ENZYME-ACTIVITY.
Cell.
207-216.
1986
-
THE TELOMERES OF THE LINEAR MITOCHONDRIAL-DNA OF TETRAHYMENA THERMOPHILA CONSIST OF 53-BP TANDEM REPEATS.
Cell.
873-883.
1986
-
RIBOZYME INHIBITORS - DEOXYGUANOSINE AND DIDEOXYGUANOSINE ARE COMPETITIVE INHIBITORS OF SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR.
Biochemistry.
4473-4477.
1986
-
THE TETRAHYMENA INTERVENING SEQUENCE RIBONUCLEIC-ACID ENZYME IS A PHOSPHOTRANSFERASE AND AN ACID-PHOSPHATASE.
Biochemistry.
4478-4482.
1986
-
MECHANISM OF RECOGNITION OF THE 5' SPLICE SITE IN SELF-SPLICING GROUP-I INTRONS.
Nature: New biology.
86-89.
1986
-
A MODEL FOR THE RNA-CATALYZED REPLICATION OF RNA.
Proceedings of the National Academy of Sciences.
4360-4363.
1986
-
NEW REACTIONS OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA AND THE MECHANISM OF SELF-SPLICING.
Journal of Molecular Biology.
143-165.
1986
-
ROLE OF CONSERVED SEQUENCE ELEMENT-9L AND ELEMENT-2 IN SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL-RNA PRECURSOR.
Cell.
167-176.
1986
-
THE GENERALITY OF SELF-SPLICING RNA - RELATIONSHIP TO NUCLEAR MESSENGER-RNA SPLICING.
Cell.
207-210.
1986
-
THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME.
Science.
470-475.
1986
-
BIOLOGICAL CATALYSIS BY RNA.
Annual Review of Biochemistry.
599-629.
1986
- THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME. Journal of Cellular Biochemistry. 88-88. 1986
-
SITES OF CIRCULARIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA IVS ARE DETERMINED BY SEQUENCE AND INFLUENCED BY POSITION AND SECONDARY STRUCTURE.
Nucleic Acids Research.
8389-8408.
1985
-
COUPLING OF TETRAHYMENA RIBOSOMAL-RNA SPLICING TO BETA-GALACTOSIDASE EXPRESSION IN ESCHERICHIA-COLI.
Science.
719-722.
1985
-
INTERMOLECULAR EXON LIGATION OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - OLIGONUCLEOTIDES CAN FUNCTION AS 5' EXONS.
Cell.
431-437.
1985
-
OLIGOMERIZATION OF INTERVENING SEQUENCE RNA MOLECULES IN THE ABSENCE OF PROTEINS.
Science.
1060-1064.
1985
-
REACTIONS OF THE INTERVENING SEQUENCE OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR - PH-DEPENDENCE OF CYCLIZATION AND SITE-SPECIFIC HYDROLYSIS.
Biochemistry.
6211-6218.
1985
-
REVERSIBILITY OF CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - IMPLICATION FOR THE MECHANISM OF SPLICE SITE CHOICE.
Cell.
639-648.
1985
-
SECONDARY STRUCTURE OF THE CIRCULAR FORM OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - A TECHNIQUE FOR RNA STRUCTURE-ANALYSIS USING CHEMICAL PROBES AND REVERSE-TRANSCRIPTASE.
Proceedings of the National Academy of Sciences.
648-652.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY INTERCALATING DYES.
Nucleic Acids Research.
7741-7758.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY METHIDIUMPROPYL.EDTA AND LOCALIZATION OF THE MAJOR DYE BINDING-SITES.
Nucleic Acids Research.
7759-7779.
1985
- SELF-SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. Federation proceedings. R10-R10. 1985
- SELF-SPLICING RNA. ACS National Meeting Book of Abstracts. 85-BIL. 1985
- SELF-SPLICING RNA. Biochemistry. 3370-3371. 1985
-
SELF-SPLICING RNA - IMPLICATIONS FOR EVOLUTION.
International Review of Cytology.
3-22.
1985
-
SEQUENCE REQUIREMENTS FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA.
Nucleic Acids Research.
1871-1889.
1985
-
A LABILE PHOSPHODIESTER BOND AT THE LIGATION JUNCTION IN A CIRCULAR INTERVENING SEQUENCE RNA.
Science.
574-578.
1984
-
CHROMATIN STRUCTURE AT THE REPLICATION ORIGINS AND TRANSCRIPTION-INITIATION REGIONS OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA.
Cell.
933-942.
1984
-
CHROMATIN STRUCTURE OF THE MOLECULAR ENDS OF OXYTRICHA MACRONUCLEAR DNA - PHASED NUCLEOSOMES AND A TELOMERIC COMPLEX.
Cell.
501-510.
1984
-
DNA - PROTEIN INTERACTIONS IN THE DROSOPHILA-VIRILIS MITOCHONDRIAL CHROMOSOME.
Nucleic Acids Research.
1991-1999.
1984
-
SPECIFIC INTERACTION BETWEEN THE SELF-SPLICING RNA OF TETRAHYMENA AND ITS GUANOSINE SUBSTRATE - IMPLICATIONS FOR BIOLOGICAL CATALYSIS BY RNA.
Nature: New biology.
820-826.
1984
-
AUTOCATALYTIC CYCLIZATION OF AN EXCISED INTERVENING SEQUENCE RNA IS A CLEAVAGE LIGATION REACTION.
Nature: New biology.
578-583.
1983
-
DIFFERENT NUCLEOSOME SPACING IN TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE IN TETRAHYMENA-THERMOPHILA.
Nucleic Acids Research.
2093-2109.
1983
-
FATE OF AN INTERVENING SEQUENCE RIBONUCLEIC-ACID - EXCISION AND CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID INTERVENING SEQUENCE INVIVO.
Biochemistry.
2390-2397.
1983
-
RNA SPLICING - 3 THEMES WITH VARIATIONS.
Cell.
713-716.
1983
- SECONDARY STRUCTURE OF A SELF-SPLICING RNA. Federation proceedings. 1884-1884. 1983
-
SECONDARY STRUCTURE OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - STRUCTURAL HOMOLOGY WITH FUNGAL MITOCHONDRIAL INTERVENING SEQUENCES.
Proceedings of the National Academy of Sciences.
3903-3907.
1983
-
TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF TETRAHYMENA RIBOSOMAL GENE CHROMATIN HAVE DIFFERENT ACCESSIBILITIES TO MICROCOCCAL NUCLEASE.
Nucleic Acids Research.
2077-2091.
1983
-
SELF-SPLICING RNA - AUTO-EXCISION AND AUTO-CYCLIZATION OF THE RIBOSOMAL-RNA INTERVENING SEQUENCE OF TETRAHYMENA.
Cell.
147-157.
1982
-
THE INTERVENING SEQUENCE EXCISED FROM THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA CONTAINS A 5'-TERMINAL GUANOSINE RESIDUE NOT ENCODED BY THE DNA.
Nucleic Acids Research.
2823-2838.
1982
- TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE OF TETRAHYMENA EXHIBIT DIFFERENT CHROMATIN STRUCTURES. Federation proceedings. 514-514. 1982
- TRANSCRIPTION AND SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. 171-204. 1982
-
ALKALINE GEL-ELECTROPHORESIS OF DEOXYRIBONUCLEIC-ACID PHOTOREACTED WITH TRIMETHYLPSORALEN - RAPID AND SENSITIVE DETECTION OF INTERSTRAND CROSS-LINKS.
Biochemistry.
1431-1437.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
REPLICATION OF THE EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILIA.
Nucleic Acids Research.
3531-3543.
1981
- SPLICING OF THE RIBOSOMAL-RNA PRECURSOR AND CYCLIZATION OF THE EXCISED INTERVENING SEQUENCE RNA IN NUCLEI OF TETRAHYMENA. Federation proceedings. 1651-1651. 1981
-
THE INTERVENING SEQUENCE OF THE RIBOSOMAL-RNA PRECURSOR IS CONVERTED TO A CIRCULAR RNA IN ISOLATED-NUCLEI OF TETRAHYMENA.
Cell.
467-476.
1981
-
CHROMATIN STRUCTURE OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA AS ANALYZED BY TRIMETHYLPSORALEN CROSSLINKING INVIVO.
Journal of Molecular Biology.
395-416.
1980
-
DNA-PROTEIN INTERACTIONS IN THE DROSOPHILA-MELANOGASTER MITOCHONDRIAL GENOME AS DEDUCED FROM TRIMETHYLPSORALEN CROSSLINKING PATTERNS.
Proceedings of the National Academy of Sciences.
4118-4122.
1980
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR IN NUCLEI OF TETRAHYMENA.
Cell.
331-338.
1980
-
An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives.
Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.
342-360.
1979
-
LOCALIZATION OF TRANSCRIBED REGIONS ON EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA BY R-LOOP MAPPING.
Proceedings of the National Academy of Sciences.
5051-5055.
1979
- Chromatin structure in living cells.. 191-8-191-8. 1978
-
Electron microscopy of DNA crosslinked with trimethylpsoralen: a probe for chromatin structure.
Biochemistry.
5313-5321.
1977
-
Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure.
Cell.
631-640.
1977
- Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.. 2644-8-2644-8. 1976
-
ORGANIZATION OF HIGHLY REPEATED SEQUENCES IN MOUSE MAIN-BAND DNA.
Journal of Molecular Biology.
227-256.
1976
-
PARTIAL DENATURATION OF MOUSE DNA IN PREPARATIVE CSCL DENSITY GRADIENTS AT ALKALINE PH.
Biochemistry.
1865-1873.
1976
-
STUDY OF DNA DENATURATION IN ULTRACENTRIFUGE.
Biopolymers.
1591-1613.
1976
-
ELECTRON-MICROSCOPIC STUDY OF MOUSE FOLDBACK DNA.
Cell.
429-446.
1975
- Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA.. 329-39-329-39. 1974
- Characterization of the most rapidly renaturing sequences in mouse main-band DNA.. 299-325-299-325. 1973
-
Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Nucleic Acids Research.
8865-8875.
2018
Teaching
courses taught
-
BCHM 4312 - Quantitative Optical Imaging
Primary Instructor - Fall 2019
Explores the fundamentals of optical imaging in biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis. MATLAB will be taught throughout the course and used for image processing. Same as MCDB 4312, MCDB 5312 and BCHM 5312. -
BCHM 5312 - Quantitative Optical Imaging
Primary Instructor - Fall 2019
Explores the fundamentals of optical imaging in biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis. MATLAB will be taught throughout the course and used for image processing. Same as MCDB 5312, MCDB 4312 and BCHM 4312. -
CHEM 6901 - Research in Chemistry
Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019
May be repeated up to 15 total credit hours. -
MCDB 4312 - Quantitative Optical Imaging
Primary Instructor - Fall 2018 / Fall 2019
Explores the fundamentals of optical imaging in biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis. MATLAB will be taught throughout the course and used for image processing. Same as BCHM 4312, MCDB 5312 and BCHM 5312. -
MCDB 5312 - Quantitative Optical Imaging
Primary Instructor - Fall 2018 / Fall 2019
Explores the fundamentals of optical imaging in biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis. MATLAB will be taught throughout the course and used for image processing. Same as BCHM 5312, MCDB 4312 and BCHM 4312.
Background
education and training
- Ph.D., University of California-Berkeley 1975
- B.A., Grinnell College 1970
awards and honors
International Activities
global connections related to teaching and scholarly work (in recent years)
- Australia Country
- Belgium Country
- Czech Republic Country
- Germany Country
- Japan Country
- Singapore Country
- Switzerland Country
- United Kingdom Country