research overview
- My research is on chromosome ends (telomeres) and their replication by telomerase.
- Contact Info
Cech, Thomas R Distinguished Professor, Nobel Laureate and Howard Hughes Medical Institute Investigator
Positions
- Distinguished Professor, Biochemistry
- Distinguished Professor, Molecular, Cellular & Developmental Biology (MCDB)
- Institute Director, Biofrontiers Institute
Research Areas
Research
keywords
- Interdisciplinary research and education
Publications
selected publications
-
chapter
- THE RNA WORLD THIRD EDITION The Nature of Modern RNA Suggests a Prebiotic RNA World Preface. Cold Spring Harbor Monograph Series. IX-X. 2006
- The RNP World. Cold Spring Harbor Monograph Series. 309-326. 2006
- Overturning the Dogma: Catalytic RNA 2001
- Building a Catalytic Active Site Using Only RNA 1999
- Structure and Mechanism of the Large Catalytic RNAs: Group I and Group II Introns and Ribonuclease P 1999
- RNA: Getting the Message 1995
- The Origin of Life and the Value of Life 1995
- Multiple Enzymatic Activities of an Intervening Sequence RNA from Tetrahymena 1987
- Viroids Contain Sequences Characteristic of Group I Introns 1987
- Ribosomal RNA Gene Expression in Tetrahymena: Transcription and RNA Splicing 1986
- Confrontational Dynamics Involved in RNA Self-Splicing 1986
- Mechanism of Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1986
- Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1983
-
conference proceeding
- TERT Promoter Mutations and Cancer. Federation proceedings. 2016
- TERT Promoter Mutations and Cancer. Federation proceedings. 2016
- MECHANISM AND STRUCTURE OF A CATALYTIC RNA MOLECULE. 91-110. 1993
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journal article
-
Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Nucleic Acids Research.
8865-8875.
2018
-
A Lifelong Passion for All Things Ribonucleic.
Cell.
14-17.
2018
-
In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure.
1275-+.
2018
-
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.
Genes and Development.
794-805.
2018
-
Dynamics of human telomerase recruitment depend on template-telomere base pairing.
Cell regulation.
869-880.
2018
-
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
Cell Reports.
3700-3707.
2017
-
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.
Nature Structural Biology.
1028-+.
2017
-
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
eLife.
2017
-
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
Nature Communications.
2017
-
How do lncRNAs regulate transcription?.
Science Advances.
2017
-
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.
Molecular Cell.
1056-+.
2017
-
Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.
Genes and Development.
59-71.
2017
-
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Cell.
1188-+.
2016
-
RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.
Cell.
1267-1279.
2016
-
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Nature Structural Biology.
286-292.
2016
-
The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.
RNA.
2007-2022.
2015
-
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Genome Biology.
2015
-
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
Genes and Development.
2219-2224.
2015
-
Protein-RNA interaction restricts telomerase from running through the stop sign.
Nature Structural Biology.
835-836.
2015
-
Nucleic acid-binding specificity of human FUS protein.
Nucleic Acids Research.
7535-7543.
2015
-
Human telomerase: biogenesis, trafficking, recruitment, and activation.
Genes and Development.
1095-1105.
2015
-
RNA World research-still evolving.
RNA.
474-475.
2015
-
Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase.
Journal of Molecular Biology.
1291-1303.
2015
- Placental Expression of the lncRNA NEAT1 Increases in Preeclampsia. Journal of the Society for Gynecologic Investigation. 201A-201A. 2015
- Placental Expression of the lncRNA NEAT1, and Not MENb or TncRNA, Increases With Gestation. Journal of the Society for Gynecologic Investigation. 189A-189A. 2015
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TERT promoter mutations and telomerase reactivation in urothelial cancer.
Science.
1006-1010.
2015
-
Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA.
Molecular Cell.
552-558.
2015
-
Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Journal of Cell Science.
331-341.
2015
-
Biochemical Properties and Biological Functions of FET Proteins.
Annual Review of Biochemistry.
355-379.
2015
-
Companies on campus.
Nature: New biology.
297-298.
2014
-
Academia and industry: Companies on campus..
Nature: New biology.
297-298.
2014
-
Identification of human TERT elements necessary for telomerase recruitment to telomeres.
eLife.
2014
-
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
Cell regulation.
2571-2578.
2014
-
Structure and Function of Steroid Receptor RNA Activator Protein, the Proposed Partner of SRA Noncoding RNA.
Journal of Molecular Biology.
1766-1785.
2014
-
The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones.
Cell.
77-94.
2014
-
Telomerase in Bladder Cancer: Back to a Better Future?.
European Urology.
370-371.
2014
-
Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.
Nucleic Acids Research.
8565-8577.
2014
-
NAR Breakthrough Article A dimeric state for PRC2.
Nucleic Acids Research.
9236-9248.
2014
-
Inhibition of Telomerase Recruitment and Cancer Cell Death.
Journal of Biological Chemistry.
33171-33180.
2013
-
Promiscuous RNA binding by Polycomb repressive complex 2.
Nature Structural Biology.
1250-U273.
2013
-
RNA Seeds Higher-Order Assembly of FUS Protein.
Cell Reports.
918-925.
2013
-
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Nucleic Acids Research.
8969-8978.
2013
-
3 ' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.
BMC Molecular Biology.
2013
-
RNA recognition by the DNA end-binding Ku heterodimer.
RNA.
841-851.
2013
-
Finding the end: recruitment of telomerase to telomeres.
Nature Reviews Molecular Cell Biology.
71-+.
2013
-
How a Chemist Looks at RNA.
Angewandte Chemie.
75-78.
2013
-
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.
Genes and Development.
2690-2695.
2012
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The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nature: New biology.
285-+.
2012
-
SnapShot: Telomeres and Telomerase.
Cell.
2012
-
The RNA Worlds in Context.
Cold Spring Harbor perspectives in biology.
2012
-
RNase P branches out from RNP to protein: organelle-triggered diversification?.
Genes and Development.
1005-1009.
2012
-
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model.
Cell.
922-932.
2012
- Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.. Cell. 922-32-922-32. 2012
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DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
Nucleic Acids Research.
235-244.
2012
- DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.. 235-44-235-44. 2012
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The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Nature Structural Biology.
1371-U84.
2011
-
Multiple POT1-TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA.
Journal of Molecular Biology.
10-17.
2011
-
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Nature: New biology.
399-+.
2011
-
Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
RNA.
298-311.
2011
-
Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants.
Molecular and Cellular Biology.
4965-4976.
2010
-
Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Proceedings of the National Academy of Sciences.
4914-4918.
2010
-
Functional interaction between telomere protein TPP1 and telomerase.
Genes and Development.
613-622.
2010
-
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
EMBO Journal.
924-933.
2010
-
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proceedings of the National Academy of Sciences.
651-656.
2010
-
Crawling Out of the RNA World.
Cell.
599-602.
2009
-
A natural ribozyme with 3 ',5 ' RNA ligase activity.
Nature Chemical Biology.
97-99.
2009
-
Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Nucleic Acids Research.
354-367.
2009
-
Evolution of biological catalysis: ribozyme to RNP enzyme..
Cold Spring Harbor Symposia on Quantitative Biology.
11-16.
2009
-
Toward predicting self-splicing and protein-facilitated splicing of group I introns.
RNA.
2013-2029.
2008
-
Mutation in TERT separates processivity from anchor-site function.
Nature Structural Biology.
871-872.
2008
-
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Molecular and Cellular Biology.
4152-4161.
2008
-
Triple-helix structure in telomerase RNA contributes to catalysis.
Nature Structural Biology.
634-640.
2008
-
On the occasion of the 25(th) anniversary of the discovery of catalytic RNA.
Biological Chemistry.
661-662.
2007
-
Local RNA structural changes induced by crystallization are revealed by SHAPE.
RNA.
536-548.
2007
-
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature: New biology.
506-510.
2007
-
Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency.
RNA.
1721-1737.
2006
- Crystal structure of an essential telomerase-specific domain of TERT. Federation proceedings. A984-A984. 2006
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Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.
RNA.
387-395.
2006
-
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Nature Structural Biology.
218-225.
2006
-
Atomic level architecture of group I introns revealed.
Trends in Biochemical Sciences.
41-51.
2006
-
RNA as a flexible scaffold for proteins: Yeast telomerase and beyond.
Cold Spring Harbor Symposia on Quantitative Biology.
217-224.
2006
-
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Nature Structural Biology.
1072-1077.
2005
-
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
Journal of Biological Chemistry.
32069-32080.
2005
-
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Proceedings of the National Academy of Sciences.
10864-10869.
2005
-
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Protein Science.
2051-2058.
2005
-
Switching human telomerase on and off with hPOT1 protein in vitro.
Journal of Biological Chemistry.
20449-20456.
2005
-
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Journal of Biological Chemistry.
5249-5257.
2005
- Fostering innovation and discovery in biomedical research.. 1390-3-1390-3. 2005
- Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biology. 2005
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Nature Structural Biology.
1223-1229.
2004
-
Structure of the Tetrahymena ribozyme: Base triple sandwich and metal ion at the active site.
Molecular Cell.
351-362.
2004
-
Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Bioscience Reports.
362-385.
2004
-
Yeast telomerase RNA: A flexible scaffold for protein subunits.
Proceedings of the National Academy of Sciences.
10024-10029.
2004
-
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
RNA.
1108-1118.
2004
-
RNA finds a simpler way.
Nature: New biology.
263-264.
2004
-
Beginning to understand the end of the chromosome.
Cell.
273-279.
2004
- Nurturing interdisciplinary research.. 1166-9-1166-9. 2004
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Tetrahymena telomerase is active as a monomer.
Cell regulation.
4794-4804.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Nature: New biology.
198-203.
2003
-
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA.
1323-1332.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA..
Nature: New biology.
198-203.
2003
-
Sequence-specific and 3 '-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit.
Biochemistry.
9269-9277.
2003
-
Human POT1 facilitates telomere elongation by telomerase.
Current Biology.
942-946.
2003
-
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Biochemistry.
5736-5747.
2003
-
Yeast telomerase is specialized for C/A-rich RNA templates.
Nucleic Acids Research.
1646-1655.
2003
-
Rebalancing teaching and research.
Science.
165-165.
2003
-
N-terminal domain of yeast telomerase reverse transcriptase: Recruitment of Est3p to the telomerase complex.
Cell regulation.
1-13.
2003
- Sharing publication-related data and materials: responsibilities of authorship in the life sciences.. 19-24-19-24. 2003
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Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.
Biochemistry.
14560-14568.
2002
-
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes and Development.
2800-2812.
2002
-
Evolution of Tetrahymena ribozyme mutants with increased structural stability.
Nature Structural Biology.
855-861.
2002
-
Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing.
Molecular and Cellular Biology.
8079-8087.
2002
-
Ribozymes, the first 20 years.
Biochemical Society Transactions.
1162-1166.
2002
-
The chemical repertoire of natural ribozymes.
Nature: New biology.
222-228.
2002
-
In vivo selection of better self-splicing introns in Escherichia coli: The role of the P1 extension helix of the Tetrahymena intron.
RNA.
647-658.
2002
-
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction..
Molecular and Cellular Biology.
2366-2374.
2002
-
Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: Evidence for product-assisted translocation.
Biochemistry.
151-161.
2002
-
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
Biochemistry.
7005-7016.
2001
-
Pot1, the putative telomere end-binding protein in fission yeast and humans.
Science.
1171-1175.
2001
-
Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry..
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].
Unit-5.1.
2001
-
Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA-solvent interactions.
Structure.
221-231.
2001
- Two RNA machines: Ribozyme and telomerase. Federation proceedings. A57-A57. 2001
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An early transition state for folding of the P4-P6 RNA domain.
RNA.
161-166.
2001
- Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry.. Unit 5.1-Unit 5.1. 2001
- Science and business. Conflicts of interest–moving beyond disclosure.. Science. 989-989. 2001
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Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
EMBO Journal.
6230-6239.
2000
-
Multiple folding pathways for the P4-P6 RNA domain.
Biochemistry.
12465-12475.
2000
-
Protection of telomeres by the Ku protein in fission yeast.
Cell regulation.
3265-3275.
2000
-
A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
Journal of Biological Chemistry.
24199-24207.
2000
-
Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.
Molecular Cell.
493-499.
2000
-
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences.
6367-6372.
2000
-
Life at the end of the chromosome: Telomeres and telomerase.
Angewandte Chemie.
34-43.
2000
- Structural biology. The ribosome is a ribozyme.. Science. 878-9-878-9. 2000
-
Quantifying the energetic interplay of RNA tertiary and secondary structure interactions.
RNA.
1665-1674.
1999
- Science at liberal arts colleges: A better education?. Daedalus. 195-216. 1999
-
Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.
EMBO Journal.
6491-6500.
1999
-
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
Genes and Development.
2863-2874.
1999
-
RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Biochemistry.
14224-14237.
1999
- Hot papers - Telomerase - Telomerase catalytic subunit homologs from fission yeast and human by T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, T.E. Cech - Comments. Scientist -Philadelphia-. 14-14. 1999
- Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature: New biology. 177-180. 1999
-
In vitro selection of RNAs with increased tertiary structure stability.
RNA.
1119-1129.
1999
-
Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Biochemistry.
8691-8702.
1999
-
Telomerase and the maintenance of chromosome ends.
Current Opinion in Cell Biology.
318-324.
1999
-
In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity.
RNA.
1481-1492.
1998
-
Two modes of survival of fission yeast without telomerase.
Science.
493-496.
1998
-
A preorganized active site in the crystal structure of the Tetrahymena ribozyme.
Science.
259-264.
1998
-
A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps.
RNA.
1179-1185.
1998
-
Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features.
Cell Chemistry Biology.
539-553.
1998
-
Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis.
Biochemistry.
11162-11170.
1998
-
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Proceedings of the National Academy of Sciences.
8479-8484.
1998
-
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.
Genes and Development.
1504-1514.
1998
-
Binding of the protein kinase PKR to RNAs with secondary structure defects: Role of the tandem A-G mismatch and noncontiguous helixes.
Biochemistry.
6303-6316.
1998
-
Euplotes telomerase: Evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation.
Biochemistry.
5162-5172.
1998
-
Telomerase and chromosome end maintenance.
Current Opinion in Genetics and Development.
226-232.
1998
-
Reversing time: Origin of telomerase.
Cell.
587-590.
1998
- Are telomeres correlative or causative in cellular senescence? General discussion. Ciba Foundation symposium. 145-147. 1998
- Human ageing and telomeres - Discussion. Ciba Foundation symposium. 139-144. 1998
- Mouse models for the study of telomerase - Discussion. Ciba Foundation symposium. 170-176. 1998
- Repair and processing events at DNA ends - Discussion. Ciba Foundation symposium. 205-208. 1998
- Telomerase and the chromosome end replication problem. Ciba Foundation symposium. 20-28. 1998
- Telomerase assays in the diagnosis and prognosis of cancer - Discussion. Ciba Foundation symposium. 155-159. 1998
- Telomeres and telomerase in other organisms. Ciba Foundation symposium. 223-226. 1998
- Telomeres in the haemopoietic system - Discussion. Ciba Foundation symposium. 219-222. 1998
-
Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis.
Biochemistry.
16345-16354.
1997
-
Peptide bond formation by in vitro selected ribozymes.
Nature: New biology.
96-100.
1997
- Polyadenylation of telomerase RNA in budding yeast. RNA. 1337-1351. 1997
- Telomerase is a true reverse transcriptase. A review. Biokhimiia (Moscow, Russia). 1202-1205. 1997
-
Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity.
Proceedings of the National Academy of Sciences.
11190-11195.
1997
-
dGTP-dependent processivity and possible template switching of Euplotes telomerase.
Nucleic Acids Research.
3698-3704.
1997
- Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1037-1051. 1997
-
A second catalytic metal ion in a group I ribozyme.
Nature: New biology.
805-808.
1997
-
Telomerase catalytic subunit homologs from fission yeast and human.
Science.
955-959.
1997
- An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis. RNA. 838-849. 1997
-
Crystals by design: A strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron.
Journal of Molecular Biology.
711-723.
1997
-
Dynamics of thermal motions within a large catalytic RNA investigated by cross-linking with thiol-disulfide interchange.
Journal of the American Chemical Society.
6259-6268.
1997
-
Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction.
Biochemistry.
8293-8303.
1997
-
Reverse transcriptase motifs in the catalytic subunit of telomerase.
Science.
561-567.
1997
-
Regulation of telomere length and function by a Myb-domain protein in fission yeast.
Nature: New biology.
744-747.
1997
-
Joining the two domains of a group I ribozyme to form the catalytic core.
Science.
847-849.
1997
-
The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers.
Molecular and Cellular Biology.
296-308.
1997
- X-ray crystallography of large RNAs: Heavy-atom derivatives by RNA engineering. RNA. 1295-1305. 1996
-
The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena.
Genes and Development.
2870-2880.
1996
-
Synthesis and characterization of an RNA dinucleotide containing a 3'-S-phosphorothiolate linkage.
Journal of the American Chemical Society.
10341-10350.
1996
-
Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes.
Nucleic Acids Research.
3722-3727.
1996
-
Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3' overhang.
Proceedings of the National Academy of Sciences.
10712-10717.
1996
-
Crystal structure of a group I ribozyme domain: Principles of RNA packing.
Science.
1678-1685.
1996
- RNA tertiary structure mediation by adenosine platforms. Science. 1696-1699. 1996
-
Mutations in the Tetrahymena ribozyme internal guide sequence: Effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.
Biochemistry.
11493-11502.
1996
-
Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.
Biochemistry.
9983-9994.
1996
- Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. RNA. 718-732. 1996
-
Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila.
EMBO Journal.
3286-3295.
1996
- Selecting apt RNAs for NMR. RNA. 625-627. 1996
-
Conformational switches involved in orchestrating the successive steps of group I RNA splicing.
Biochemistry.
3754-3763.
1996
-
Method for determining RNA 3' ends and application to human telomerase RNA.
Nucleic Acids Research.
532-533.
1996
-
Exocyclic amine of the conserved G center dot U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization.
Biochemistry.
1201-1211.
1996
-
Assembly of a ribonucleoprotein catalyst by tertiary structure capture.
Science.
345-348.
1996
- Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(IIe) of the purple bacterium Azoarcus. RNA. 74-83. 1996
-
RELATIVE ORIENTATION OF RNA HELICES IN A GROUP-I RIBOZYME DETERMINED BY HELIX EXTENSION ELECTRON-MICROSCOPY.
EMBO Journal.
4849-4859.
1995
-
TELOMERASE AND DNA END REPLICATION - NO LONGER A LAGGING-STRAND PROBLEM.
Science.
1533-1534.
1995
- IDENTIFICATION OF RIBOZYMES WITHIN A RIBOZYME LIBRARY THAT EFFICIENTLY CLEAVE A LONG SUBSTRATE RNA. RNA. 598-609. 1995
-
PROTEIN FACILITATION OF GROUP-I INTRON SPLICING BY ASSEMBLY OF THE CATALYTIC CORE AND THE 5'-SPLICE-SITE DOMAIN.
Cell.
221-230.
1995
-
TELOMERASE RNA LOCALIZED IN THE REPLICATION BAND AND SPHERICAL SUBNUCLEAR ORGANELLES IN HYPOTRICHOUS CILIATES.
Journal of Cell Biology.
243-253.
1995
-
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Biochemistry.
6211-6218.
1985
-
REVERSIBILITY OF CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - IMPLICATION FOR THE MECHANISM OF SPLICE SITE CHOICE.
Cell.
639-648.
1985
-
SECONDARY STRUCTURE OF THE CIRCULAR FORM OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - A TECHNIQUE FOR RNA STRUCTURE-ANALYSIS USING CHEMICAL PROBES AND REVERSE-TRANSCRIPTASE.
Proceedings of the National Academy of Sciences.
648-652.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY INTERCALATING DYES.
Nucleic Acids Research.
7741-7758.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY METHIDIUMPROPYL.EDTA AND LOCALIZATION OF THE MAJOR DYE BINDING-SITES.
Nucleic Acids Research.
7759-7779.
1985
- SELF-SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. Federation proceedings. R10-R10. 1985
- SELF-SPLICING RNA. ACS National Meeting Book of Abstracts. 85-BIL. 1985
- SELF-SPLICING RNA. Biochemistry. 3370-3371. 1985
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SELF-SPLICING RNA - IMPLICATIONS FOR EVOLUTION.
International Review of Cytology.
3-22.
1985
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SEQUENCE REQUIREMENTS FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA.
Nucleic Acids Research.
1871-1889.
1985
-
A LABILE PHOSPHODIESTER BOND AT THE LIGATION JUNCTION IN A CIRCULAR INTERVENING SEQUENCE RNA.
Science.
574-578.
1984
-
CHROMATIN STRUCTURE AT THE REPLICATION ORIGINS AND TRANSCRIPTION-INITIATION REGIONS OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA.
Cell.
933-942.
1984
-
CHROMATIN STRUCTURE OF THE MOLECULAR ENDS OF OXYTRICHA MACRONUCLEAR DNA - PHASED NUCLEOSOMES AND A TELOMERIC COMPLEX.
Cell.
501-510.
1984
-
DNA - PROTEIN INTERACTIONS IN THE DROSOPHILA-VIRILIS MITOCHONDRIAL CHROMOSOME.
Nucleic Acids Research.
1991-1999.
1984
-
SPECIFIC INTERACTION BETWEEN THE SELF-SPLICING RNA OF TETRAHYMENA AND ITS GUANOSINE SUBSTRATE - IMPLICATIONS FOR BIOLOGICAL CATALYSIS BY RNA.
Nature: New biology.
820-826.
1984
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AUTOCATALYTIC CYCLIZATION OF AN EXCISED INTERVENING SEQUENCE RNA IS A CLEAVAGE LIGATION REACTION.
Nature: New biology.
578-583.
1983
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DIFFERENT NUCLEOSOME SPACING IN TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE IN TETRAHYMENA-THERMOPHILA.
Nucleic Acids Research.
2093-2109.
1983
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FATE OF AN INTERVENING SEQUENCE RIBONUCLEIC-ACID - EXCISION AND CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID INTERVENING SEQUENCE INVIVO.
Biochemistry.
2390-2397.
1983
-
RNA SPLICING - 3 THEMES WITH VARIATIONS.
Cell.
713-716.
1983
- SECONDARY STRUCTURE OF A SELF-SPLICING RNA. Federation proceedings. 1884-1884. 1983
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SECONDARY STRUCTURE OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - STRUCTURAL HOMOLOGY WITH FUNGAL MITOCHONDRIAL INTERVENING SEQUENCES.
Proceedings of the National Academy of Sciences.
3903-3907.
1983
-
TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF TETRAHYMENA RIBOSOMAL GENE CHROMATIN HAVE DIFFERENT ACCESSIBILITIES TO MICROCOCCAL NUCLEASE.
Nucleic Acids Research.
2077-2091.
1983
-
SELF-SPLICING RNA - AUTO-EXCISION AND AUTO-CYCLIZATION OF THE RIBOSOMAL-RNA INTERVENING SEQUENCE OF TETRAHYMENA.
Cell.
147-157.
1982
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THE INTERVENING SEQUENCE EXCISED FROM THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA CONTAINS A 5'-TERMINAL GUANOSINE RESIDUE NOT ENCODED BY THE DNA.
Nucleic Acids Research.
2823-2838.
1982
- TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE OF TETRAHYMENA EXHIBIT DIFFERENT CHROMATIN STRUCTURES. Federation proceedings. 514-514. 1982
- TRANSCRIPTION AND SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. 171-204. 1982
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ALKALINE GEL-ELECTROPHORESIS OF DEOXYRIBONUCLEIC-ACID PHOTOREACTED WITH TRIMETHYLPSORALEN - RAPID AND SENSITIVE DETECTION OF INTERSTRAND CROSS-LINKS.
Biochemistry.
1431-1437.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
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INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
REPLICATION OF THE EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILIA.
Nucleic Acids Research.
3531-3543.
1981
- SPLICING OF THE RIBOSOMAL-RNA PRECURSOR AND CYCLIZATION OF THE EXCISED INTERVENING SEQUENCE RNA IN NUCLEI OF TETRAHYMENA. Federation proceedings. 1651-1651. 1981
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THE INTERVENING SEQUENCE OF THE RIBOSOMAL-RNA PRECURSOR IS CONVERTED TO A CIRCULAR RNA IN ISOLATED-NUCLEI OF TETRAHYMENA.
Cell.
467-476.
1981
-
CHROMATIN STRUCTURE OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA AS ANALYZED BY TRIMETHYLPSORALEN CROSSLINKING INVIVO.
Journal of Molecular Biology.
395-416.
1980
-
DNA-PROTEIN INTERACTIONS IN THE DROSOPHILA-MELANOGASTER MITOCHONDRIAL GENOME AS DEDUCED FROM TRIMETHYLPSORALEN CROSSLINKING PATTERNS.
Proceedings of the National Academy of Sciences.
4118-4122.
1980
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INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR IN NUCLEI OF TETRAHYMENA.
Cell.
331-338.
1980
-
An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives.
Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.
342-360.
1979
-
LOCALIZATION OF TRANSCRIBED REGIONS ON EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA BY R-LOOP MAPPING.
Proceedings of the National Academy of Sciences.
5051-5055.
1979
- Chromatin structure in living cells.. 191-8-191-8. 1978
-
Electron microscopy of DNA crosslinked with trimethylpsoralen: a probe for chromatin structure.
Biochemistry.
5313-5321.
1977
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Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure.
Cell.
631-640.
1977
- Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.. 2644-8-2644-8. 1976
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ORGANIZATION OF HIGHLY REPEATED SEQUENCES IN MOUSE MAIN-BAND DNA.
Journal of Molecular Biology.
227-256.
1976
-
PARTIAL DENATURATION OF MOUSE DNA IN PREPARATIVE CSCL DENSITY GRADIENTS AT ALKALINE PH.
Biochemistry.
1865-1873.
1976
-
STUDY OF DNA DENATURATION IN ULTRACENTRIFUGE.
Biopolymers.
1591-1613.
1976
-
ELECTRON-MICROSCOPIC STUDY OF MOUSE FOLDBACK DNA.
Cell.
429-446.
1975
- Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA.. 329-39-329-39. 1974
- Characterization of the most rapidly renaturing sequences in mouse main-band DNA.. 299-325-299-325. 1973
-
Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Nucleic Acids Research.
8865-8875.
2018
Teaching
courses taught
- CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2019)
- CHEM 6901 Research in Chemistry (Spring 2019)
- CHEM 8991 Doctoral Dissertation (Spring 2019)
- MCDB 4840 Upper-Division Independent Study (Spring 2019)
- MCDB 4990 Honors Thesis (Spring 2019)
- MCDB 7840 Graduate Independent Study (Spring 2019)
- MCDB 8990 Doctoral Dissertation (Spring 2019)
- CHEM 4901 Independent Study in Chemistry and Biochemistry (Fall 2018)
- CHEM 6901 Research in Chemistry (Fall 2018)
- CHEM 8991 Doctoral Dissertation (Fall 2018)
- MCDB 2840 Lower-Division Independent Study (Fall 2018)
- MCDB 4312 Quantitative Optical Imaging (Fall 2018)
- MCDB 5312 Quantitative Optical Imaging (Fall 2018)
- MCDB 7840 Graduate Independent Study (Fall 2018)
- CHEM 4901 Independent Study in Chemistry and Biochemistry (Summer 2018)
- CHEM 6901 Research in Chemistry (Summer 2018)
- CHEM 8991 Doctoral Dissertation (Summer 2018)
- MCDB 4840 Upper-Division Independent Study (Summer 2018)
- CHEM 4901 Independent Study in Chemistry and Biochemistry (Spring 2018)
- CHEM 6901 Research in Chemistry (Spring 2018)
- CHEM 8991 Doctoral Dissertation (Spring 2018)
- MCDB 4840 Upper-Division Independent Study (Spring 2018)
- MCDB 4990 Honors Thesis (Spring 2018)
- MCDB 7840 Graduate Independent Study (Spring 2018)
- MCDB 8990 Doctoral Dissertation (Spring 2018)
Background
education and training
- Ph.D., University of California-Berkeley 1975
- B.A., Grinnell College 1970
awards and honors
International Activities
global connections related to teaching and scholarly work (in recent years)
- Australia Country
- Belgium Country
- Czech Republic Country
- Germany Country
- Japan Country
- Singapore Country
- Switzerland Country
- United Kingdom Country